痛风清消颗粒治疗湿热蕴结型急性痛风性关节炎的临床观察

The Clinical Observations on Acute Gouty Arthritis of Damp-Heat Accumulation Type

目的观察痛风清消颗粒治疗湿热蕴结型急性痛风性关节炎的临床疗效和安全性。方法 80例湿热蕴结型急性痛风性关节炎患者随机分为治疗组和对照组,每组40例。治疗组口服痛风清消颗粒10g,每日两次;对照组口服双氯芬酸钠片75mg,每日两次。10天为1个疗程,共2个疗程。治疗前后分别进行中医症状积分评定。实验室观察指标包括WBC、BUA、ESR、hsCRP、BUN、Scr、ALT等,并记录发生的不良反应。结果两组治疗后组间统计学比较差别有显著性意义(P驥0.05),组内比较WBC、BUA、ESR、hs-CRP提示差别有极显著性意义(P驥0.01)。两组治疗前后安全性评估ALT、Scr、BUN差别无显著性意义(P驦0.05),中医症状评定治疗组总有效率(97.5%)优于对照组(82.5%),差别有显著性意义(P驥0.05),而治疗组不良反应率更低。结论痛风清消颗粒治疗湿热蕴结型急性痛风性关节炎效果良好且安全性高,值得临床推广。

Objectives To observe the clinical efficacy and safety of Tongfengqingxiao granules on damp-heat accumulation type of acute gouty arthritis （AGA） . Methods 80 patients of damp-heat accumulation type of AGA were randomly divided into two groups, 40 pa-tients in each group. The treatment group was oral y taken with Tongfengqingxiao granules;10g twice a day while the control group was treated with Diclofenac sodium sustained released tablet, 75mg twice a day. 10 day for a course and total y two courses. The TCM symp-tom assessments were compared before and after treatment respectively. The laboratory indexes such as WBC, BUA, ESR, hs-CRP, BUN, Scr, ALT were observed. Adverse reactions were recorded daily. Results There were significant differences between two groups in WBC, BUA, ESR, hs-CRP after the treatment （ P 〈0.05） . Both groups had very significant differences in WBC, BUA, ESR, hs-CRP after treatment （P 〈0.01） . The safety evaluation indexes such as the ALT, Scr, BUN had no significant differences between two groups before and after treatment （ P 〈0.05） . The TCM symptom assessments of two groups had significant differences （ P〈0.05） while the treatment group had lower adverse effects. Conclusions The Tongfengqingxiao Granules had good curative effect and safety in AGA with damp-heat accumulation. It is worthy of clinical promotion.