女性系统性红斑狼疮患者血清hs-CRP水平与认知功能障碍相关性的临床研究

The relations between the serum hs-CRP level and cognitive impairment in female patients with systemic lupus erythema-tosus

目的探明我国女性系统性红斑狼疮（SLE）患者血清hs-CRP水平与认知功能障碍之间的相关性，为临床早期诊断和治疗提供实验依据。方法根据所检测90位SLE患者hs-CRP水平，将其分为A组：hs-CRP正常组（0～3mg／L）；B组：hs-CRP轻度升高组（3～10mg／L）；C组：hs-CRP明显升高组（〉10mg／L），并同步采用蒙特利尔（MoCA）方法进行认知功能的评估并进行统计学分析。结果在90例SLE女性患者中，其中68.89％的患者出现了不同程度的认知功能障碍。A、B、C三组患者的认知功能评分的差异存在统计学意义（P〈0.05）。其中，A组平均得分最高，B组中等，C组得分最低。血清hs—CRP浓度水平与认知功能之间负相关（偏相关系数r=0．2715，P一0．012）；同样在多重线性回归研究中发现，hs—CRP水平对认知功能的影响是有统计学意义的（标准化偏回归系数β＇=-0．299，P=0.006）；A、B、C3组患者主要表现在视觉空间与执行功能、命名能力、注意力、记忆力及定向力方面的差异有统计学意义（P〈0．05）。血清hs—CRP浓度水平与SLE的病情活动程度不存在相关关系（r=0．019，P=0．859）。结论在无其他中枢神经系统症状的女性SLE患者中，有68．89％的患者存在不同程度的知功能障碍。主要表现为空间与执行功能、命名能力、注意力、记忆及定向力等方面。女性SLE患者认知功能障碍与血清hs—CRP水平存在负相关，即hs—CRP水越高认知水平越低，但与SLE病情活动程度无相关关系。

Objective To explore the relationship between the serum hs-CRP level and cognitive impairment in female SLE patients. Methods The 90 female SLE cases were divided into three groups according to the serum hs- CRP level： group A（hs-CRP≤3 rag/L）, group B（3 mg/L〈hs-CRP〈 10 rag/L） and group C（hs-CRP≥10 rag/L） and their conigitive functions were appraised simultaneously by the Montreal Cognitive Assessment（MoCA）. The data i- tems were analysed statistically by SPSSll. 0 software. Results 68.89% of 90 cases presented cognitive impairment. Comparing with three groups, there were significant differences in cognitive impairment（P〈0.05）. Among the three groups, the MoCA scores of group A was the highest, group B median and the group C the lowest. We found that the significant negative correlation between the serum hs-CRP level and cognitive impairment（Partial correlation coeffi- cient r=0. 271 5,P=0.012）. With the method of regression analyses,we also found that the correlation between the hs-CRP level and MoCA scores of cognitive functions was a linear association（Standardized partial regression co-efficient β＇=0.299,P=0.00G）. In many aspects of cognitive impairment including space and executive functions, na- ming ability, attention, memory and orientation, SLE patients of groups of A, B and C were significant differences sta- tistically（P〈0. 001～0.05）. There was no correlation between serum hs-CRP level and disease activity of SLE（r=0.019,P=0.859. Conclusion GS. 89% of female SLE patients presented cognitive impairment in various degrees. Main aspects of cognitive impairment included space and executive functions, naming ability, attention, memory and o- rientation. There was a significant negative correlation between the serum hs-CRP level and cognitive function in SLE patients, such as the serum hs-CRP level is higher, cognitive function is lower, but there was no correlation between serum hs-CRP level and disease activity of SLE.