缺铁性贫血患者血清脂代谢指标和Lp—PLA2水平的检测对动脉粥样硬化风险的预测价值

The value of serum level of lipoprotein profile and Lp-PLA2 in predicting risk of atherosclerosis among patients with irondeficiency anemia

目的通过检测缺铁性贫血（IDA）患者血清动脉粥样硬化相关的脂质代谢指标及脂蛋白相关磷脂酶A2（Lp—PLA2）的水平，探讨IDA是否存在动脉粥样硬化的风险。方法选取IDA患者（80例）和健康对照者（80例）为研究对象，检测血清脂代谢相关指标及Lp-PLA2水平，并进行组问比较，分析其相关性。结果IDA组的TG水平高于健康对照组（0.99±0.26和0.83±0.26mmol／L，P〈0.05），HDL-C水平低于健康对照组（1.5±0．2和1.7±0.3，P〈0.01）。IDA组血清Lp-PLA2活性（36.4±5.6和33.33±5.9μmol／min／L，P〈0.05）和含量（128±34和111±31ng／mL，P〈0.05）高于健康对照组。Lp—PLA2活性和含量与血红蛋白浓度呈负相关（r=-0.29／r=-0.33，P〈0.05），与HDL—C呈负相关（r=-0.38／r=-0.35，P〈0.05），与LDL—C呈正相关（r=0.41／r=0.36，P〈0.05）。结论IDA患者体内存在脂质代谢异常，血清Lp—PLA2水平明显升高，可能存在动脉粥样硬化的风险。

Objective Detection of the lipid-related atherogenic risk factors and the serum level of lipoprotein associated phospholipase A2（Lp-PLA2）in iron deficiency anemia patients,to explore whether IDA is the risk factor of atherogenic. Methods Eighty IDA women were compared with the healthy age-matched controls. Lipoprotein pro file and level of Lp-PLA2 were measured and evaluated. Results Triglycerides（0.99±0.26 vs. O. 83±0.26 mmol/L, P〈0.05）were higher and HDL-C（1.5±0.2 vs. 1.7±0.3,P〈O.01）lower in the patients group. In IDA patients,the Lp-PLA2 mass and activity were increased, correlated negatively with hemoglobin and HDL-C, while positively asso ciated with LDL-C. Conclusion The alterations in lipoprotein profile,and level of Lp-PLA2 described in the present study indicate that non-treated IDA might represent a proatherogenic state.