氯吡格雷联合阿司匹林治疗不稳定型心绞痛的临床观察

The Efficacy of Clopidogrel Plus Aspirin in the Treatment of Unstable Angina

目的:探讨氯吡格雷联合阿司匹林治疗不稳定型心绞痛的疗效。方法:选取2013年4月-2014年4月在笔者所在医院住院治疗的不稳定型心绞痛患者82例,将入选的82例不稳定型心绞痛患者随机分为观察组和对照组,每组41例。两组均予镇静、吸氧及硝酸酯类、β受体阻滞剂、钙离子拮抗剂、调脂药物、低分子肝素抗凝及活血化瘀药物。对照组予阿司匹林0.1 g口服,1次/d。观察组在此基础上联合氢氯吡格雷75 mg口服,1次/d,共6周。比较两组心绞痛患者治疗后的疗效及两组患者心绞痛发作频率、心绞痛平均发作持续时间。结果:观察组治疗后的总有效率达92.7%,对照组的总有效率75.6%,两组疗效比较差异有统计学意义(P<0.05)。观察组患者的心绞痛发作频率、心绞痛平均发作持续时间均较对照组显著低(P<0.05)。结论:氯吡格雷联合阿司匹林治疗不稳定型心绞痛具有较好的疗效,值得推广和应用。

Objective：To evaluate the efficacy of Clopidogrel plus Aspirin in the treatment of unstable angina.Method：82 cases of patients with angina pectoris from April 2013 to April 2014 in our hospital were selected as study object,82 cases UAP patients were randomly divided into observation group and control group,41 cases in each group.Two groups were treated with sedation,oxygen and nitric acid vinegar,β-blockers,calcium antagonists,lipid lowering drugs,low molecular weight heparin and blood of fatigue drugs.The control group was given Aspirin 0.1 g orally,once daily.The observed group was given 75 mg Clopidogrel Hydrogen orally,once daily,for 6 weeks on the basis of control group.The efficacy and attack frequency of angina,the average duration of attack of angina seizure were compared between two groups.Result：After treatment,the total effective rate of observation group was 92.7%,the control group was 75.6%,there was statistical significant in two groups（P〈0.05）.The angina attack frequency,the average duration of attack of angina of observation group were significantly lower than the control group（P〈0.05）.Conclusion：Clopidogrel plus Aspirin in the treatment of unstable angina has a good effect.