硫酸头孢喹肟乳房注入剂在牛奶中的药代动力学研究

Pharmacokinetics of Cefquinome Sulfate Intramammary Infusion in Milk

为研究硫酸头孢喹肟乳房注入剂给药后在乳区的分布情况，进行了奶牛牛奶中药物的药动学研究。选取8头健康黑白花奶牛，每头牛随机选择两个乳区，以每个乳区1支（8g ∶75 mg／支）的剂量进行单次乳房灌注给予硫酸头孢喹肟乳房注入剂。采用超高效液相色谱－串联质谱（ UP LC－MS／MS）方法检测乳中头孢喹肟的浓度。结果表明，该制剂采用单次乳房灌注给药后，给药乳区测得24～30 h之内乳中头孢喹肟的平均浓度在1．51～2．76μg／mL之间；未给药乳区仅在给药后12和24 h能够检测到较低水平的药物含量（分别为0．05±0．01和0．02±0．01μg／mL，n＝4）；血液中仅在6和12 h检测到较低水平的药物含量（分别为0．05±0．03和0．03±0．01μg／mL，n＝4）；说明药物主要集中在给药乳区，进入体循环及未给药乳区的量及其微少。

Pharmacokinetic in cow milk was evaluated to study the distribution of cefquinome sulfate intramammary infusionin in mammary region after administration. 8 healthy black-white cows and two mammary regions of each cow were randomly selected. A single intramammary infusion of 8 g cefquinome sulfate intramammary infusion was given on each mammary region. Concentration of cefquinome was detected by the method of high performent liquid chromatography and mass spectrometer （ UP LC -MS/MS ） . The mean concentration of cefquinome was 1. 51-2. 76 μg/mL in mammary region 24 ~ 30 h after administration; while lower drug concentrations of （0.05±0.01） μg/mL and （0.02±0.01） μg/mL were found in mammary region not administrated with drug at 12 and 24 h;in blood, the lower drug contents of （0.05±0.03） μg/mL and （0.03±0.01） μg/mL-1 were detected at 6 and 12 h. The results demonstrated that cefquinome was mainly concentrated in mammary region after administration and rarely drug entered mammary region without administration and systemic circulation.