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iPS细胞诱导的肿瘤干细胞模型及应用 被引量：1

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摘要 肿瘤干细胞(Cancer stem cells,CSCs)被认为是一小群具有自我更新能力及无限分化能力,并形成异质性肿瘤的细胞。基于微环境对干细胞及肿瘤细胞的重要影响作用,本课题组以日本学者山中伸弥教授课题组开发出的NanogmiPS(Mouse induced pluripotent stem cell s,miPS)细胞系为研究材料,模拟肿瘤干细胞微环境诱导出具有肿瘤干细胞特性的miPS-CSCs细胞模型。本文对近年来关于CSCs模型方面的研究做一综述,比较不同模型建立的方法,并探讨肿瘤干细胞模型对于CSCs微环境及CSCs与肿瘤细胞间相互作用机制的研究,对于新生血管形成的研究等方面的意义,以及抗CSCs肿瘤药物筛选和针对CSCs疫苗开发的应用前景及临床意义。
作者 陈凌
机构地区 天津市中心妇产科医院病理科
出处 《中国城乡企业卫生》 2014年第6期26-27,共2页 Chinese Journal of Urban and Rural Enterprise Hygiene
关键词 肿瘤干细胞 微环境 干细胞模型 MIPS
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
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参考文献15

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同被引文献37

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中国城乡企业卫生
2014年 第6期

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