抗结核药物所致肝损害129例临床分析

Clinical analysis of 129 cases of liver damage caused by anti-tuberculosis drugs

目的探讨抗结核药致药物性肝损害（DILI）的临床特点。方法回顾分析我科129例肺结核患者在抗结核治疗过程中发生DILI的临床资料。结果高龄、嗜酒、肝炎病毒携带者或有肝病史、抗结核药物治疗的1~3周、血行播散型肺结核更易发生药物性肝损害。结论对抗结核药致DILI的早期诊断和及时合理治疗,以保证患者能够顺利完成化疗。

Objective to investigate the drug-induced liver damage caused by anti- tuberculosis drugs （DILI） clinical characteristics. Methods Retrospective analysis clinical data of 129 cases of pulmonary tu- berculosis patients in our department with the occurrence of DILl in anti tuberculosis treatment process. Re- suits the elderly,drinking, hepatitis B virus carriers or a history of liver disease,anti-tuberculosis drug treatment of line 1 -3 weeks, disseminated blood type lung tuberculosis more susceptible to drug-induced liv- er injury. Conclusions early diagnosis of DILl induced by anti- tuberculosis drugs and proper treatment, to ensure that patients can be successfully completed chemotheraov.