期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

3β-羟基-孕甾-5-烯-20R-胺的合成与结构归属 被引量：1

Synthesis and Structural Assignment of 3β-Hydroxypregn-5-en-20R-amine
下载PDF
导出
摘要 利用3β-羟基-孕甾-5-烯-20-酮与盐酸羟胺反应生成3β-羟基-孕甾-5-烯-20-酮肟,以镍铝合金粉为催化剂将3β-羟基-孕甾-5-烯-20-酮肟还原成3β-羟基-孕甾-5-烯-20R-胺,通过1H NMR、13C NMR和2D NMR技术对其结构进行解析并归属碳谱和氢谱数据。 Abstract：3β-Hydroxypregn-5-en-20R-amine was catalyzed by Nickel Aluminum alloy power and synthesized from 3β- hydroxypregn-5-en-20-oxime,whieh was prepared from steroid material 313-hydroxypregn-5-en-20-one and hydroxylamine hydrochloride. The detailed analysis and assignments were made by using ^1H NMR, ^13C NMR and 2D NMR technology.
作者 徐向伟 林雪梅 刘光 陈慧颖 赵有为 罗丹 葛文中
机构地区 黑龙江八一农垦大学生命科学技术学院
出处 《黑龙江八一农垦大学学报》 2014年第6期77-80,共4页 journal of heilongjiang bayi agricultural university
基金 黑龙江省教育厅(大学生创新创业训练计划:胺基甾体的生物转化及抗肿瘤作用研究)
关键词 合成 甾体胺 2D NMR 归属 synthesis steroidal amine 2D NMR assignment
分类号 R914.4 [医药卫生—药物化学]
  • 相关文献

参考文献6

二级参考文献119

  • 1肖定军,彭学东,邓松之,马伟杰,吴厚铭.中国南海海绵Cinachyrella australiensis中(3E)-胆甾-4-烯-3,6-二酮-3-肟的结构鉴定[J].有机化学,2005,25(12):1606-1609. 被引量：9
  • 2[1]He Q,Jiang D.A novel aminosteriod is active for proliferation inhibition and differentiation induction of human acute myeloid HL-60 cells[J].Leuk Res,1999,23 (4):369-372.
  • 3[3]Rowley P T,Ohlsson-Wilhelm B M,Fareley B A,et al.Inducers of erthriod differentiation in K562 human leukemia cells[J].Exp Hematol,1981,9(1):32-37.
  • 4[4]Warrell R P Jr,de The H,Wang Z Y,et al.Acute promyelocytic leukemia[J].N Engl J Med,1993,329(3):177-189.
  • 5[5]Attadia V.Effects of 5-aza-2 ' -deoxycytidine on differentiation and oncogene expression in the human monoblastic leukemia cell line U-937[J].Leukemia,1993,7 (Suppl 1):9-16.
  • 6[6]Jiang P,Gan M,Huang H,et al.Proteome analysis of antiproliferative mechanism of 12-O-tetradecanoylphorbol 13-acetate on cultured nasopharyngeal carcinoma CNE2 cells[J].JProteome Res,2005,4(2):599-605.
  • 7[7]Darby T G,Meissner J D,Ruhlmann A,et al.Functional interference between retinoic acid and steroid hormone receptors and the oncoprotein Fli-1[J].Oncogene,1997,15(25):3067-3082.
  • 8[8]Sharifi S,Dzik W H,Sadrzadeh S M.Human plasma and Tirilazad mesylate protect stored human erythrocytes against the oxidative damage of gamma-irradiation[J].Transfusion Medicine,2000,10 (2):125-130.
  • 9[9]Ngo P L,Chen H,Qi S,et al.Effects of the 21-aminosteroid U74389G in a model of chronic myocardial infarction in the rat[J].J Cardiovase Pharmacol,1999,34 (6):857 -863.
  • 10[10]Gonzalez Deniselle M C,Gonzalez S L,De Nicola A F.Cellular basis of steroid neuroprotection in the wobbler mouse,a genetic model of motoneuron disease[J].Cell Mol Neurobiol,2001,21(3):237-254.

共引文献47

同被引文献15

  • 1葛文中,李楠,单丽红,刘宏民.总状毛霉对4-烯-3-酮甾体的生物转化研究[J].微生物学报,2007,47(3):540-543. 被引量：9
  • 2Jianguo Cui,Lei Fan,Liliang Huang,et al. Synthesis and evaluation of some steroidal oximes as cytotoxic agents: Structure/activity studies(I) [ J ].Streoids, 2009,74: 62-72.
  • 3Jianguo Cui,Lei Fan,Yanmin Huang,et al. Synthesis and e- valuation of some steroidal oximes as cytotoxic agents:struc- ture/activity studies (11) [ J ] .Steroids, 2009,74: 989-995.
  • 4Ktstic N M,Bjelakovic M S,Zizak Z,et al. Synthesis of some steroidal oximes,lactams,thiolactams and their anti- tumor activities[ J ]. Steroids, 2007,72 : 406-414.
  • 5Ktstic N M,Bjelakovic M S,Milan M D,et al. Photochemi- cal and Beckmann rearrangement of (Z)-cholest-4-en-6- one oxime[J]. J Serb Chem Soc,2004,69(6):413-420.
  • 6Haq Nawaz B, Rasheed A K. Biological transformations of steroid compounds:A review [J]. Steroid,2012,76: 1267-1290.
  • 7Mathew P L, Bertrand L, Simon P N, et al. Anti-cancer ac- tivities of novel D-ring modified 2-substituted estrogen-3- O-sulfamates. J [J]. Steroid Biochem. Mol. Bio,2005,94: 239-251.
  • 8Faramarzi M A,Badiee M,Yazdi M T,et al. Formation of hydroxysteroid derivatives from androst-4-en-3,17-dione by the filamentous fungus Mucor racemosus [J ]. J. Mol Cat B : Enzym, 2008,50:7-12.
  • 9Torshabi M, Badice M, Faramarzi M A. Biotransformation of methyhestosterone by the filamentous fungus Mucor racemosus [J]. Chemistry of Nanture Compounds,2011 (47):59-62.
  • 10Roopesh K,Ramachandran S,Nampoothiri K M,et al. Comparison of phytase production on wheat bran and oil- cakes in solid-state fermentation by Mucor racemasus [J ]. Bioresour Technol, 2006,97 (3) : 506-511.

引证文献1

黑龙江八一农垦大学学报
2014年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部