匍枝千里光的生物碱研究

Study on Alkaloids of Senecio Filiferus

目的对千里光属中匍枝千里光的生物碱进行研究。方法使用常压硅胶柱层析法对匍枝千里光乙醇提取物的二氯甲烷萃取部分的化学成分进行分离和纯化,通过理化方法和核磁共振(NMR)对分离得到的化合物进行结构鉴定。结果从匍枝千里光中分离并鉴定了3个新的生物碱(人工产物)N-氯甲基-9-当归酰矛蟹甲草裂碱氯化物(P-1)、N-氯甲基瓶草千里光碱氯化物(P-2)、N-氯甲基瓶草千里光新碱氯化物(P-3)和1个已知的吡咯里西啶生物碱9-当归酰阔叶千里光裂碱(P-4)。结论 4个吡咯里西啶生物碱化合物均为首次从匍枝千里光中经二氯甲烷处理后分离得到。

OBJECTIVE To investigate the alkaloids of Senecio filiferus Franch.METHODS The chemical composition of dichloromethane extraction part of Senecio filiferus Franch.ethanol extract were separated and purified by silica gel column chromatography,and the chemical structures of isolated compounds were identified by physicochemical methods and nuclear magnetic resonance （NMR）.RESULTS Three new alkaloids as artificial products （N-chloromethene-9-angelylplatynecine） chloridate （P-1）,（N-chloromethenesarracine） chloridate （P-2） and （N-chlorometheneneosarracine）-chloridate （P-3）,as well as a known pyrrolizidine alkaloid 9-angelylplatynecine （P-4） was isolated and identified from Senecio filiferus Franch.CONCLUSION Four pyrrolizidine alkaloids were all first isolated from Senecio filiferus Franch.after the treatment of dichloromethane.