通便颗粒治疗慢性功能性便秘40例

Study of Tongbian Granules in the Treatment of Chronic Functional Constipation

目的观察通便颗粒治疗慢性功能性便秘(CFC)的临床疗效。方法 120例CFC患者被随机分为通便颗粒组、麻仁软胶囊组和莫沙必利组,疗程均为60d。观察3组用药前后大便性状、每次排便时间、排便间隔时间和排便困难程度等指标,比较治疗后3组便秘的临床疗效及不良反应。结果通便颗粒组明显改善便秘的症状积分(P<0.01),总有效率达94.7%,与阳性对照组相比具有统计学意义(P<0.05),且无不良反应发生。结论通便颗粒治疗CFC,疗效显著,值得临床推广应用。

OBJECTIVE To evaluate the effect of Tongbian granules in the treatment of chronic Functional constipation.METHODS 120 patients with chronic constipation were randomly assigned to 3 groups：Tongbian granules group,Maren Soft capsule group and Mosapride group.The treatment course of each group was sixty days.The three groups were compared in the index of fecal character,time for defecation and intervals,difficulty of defecate,and the clinical effect of each group were evaluated and adverse reactions rate were also included （P〈C.01）.RESULTS After statistical analysis,it was found that Tongbian granules group can improve constipation symptom score.The total effective rate of Tongbian granules group was 94.7% （P〈0.01） compared with the positive control group.CONCLUSION With the differentiation of symptoms and signs,Tongbian granules are effective in treating chronic constipation and worth of clinical application.