吉林省结核分枝杆菌对乙胺丁醇耐药状况分析

Analysis of ethambutol resistance in mycobacterium tuberculosis of Jilin province

目的获得吉林省结核病乙胺丁醇耐药本底数据,评价现行结核病控制策略的效果。方法按照世界卫生组织/国际防痨和肺病联合会(WHO/IUATLD)的通行标准,采用分层整群抽样方法,获得覆盖全省各地区结核分枝杆菌,对其进行菌型鉴定及乙胺丁醇(EMB)药物敏感性测试。结果收集到临床分离的结核分枝杆菌菌株1 772株,EMB总体耐药率为6.83%;其中来自初治涂阳肺结核患者菌株为1 175株(66.14%),EMB耐药率为4.34%;来自复治涂阳肺结核患者菌株597株(33.69%),复治耐药率为11.73%。结论吉林省结核分枝杆菌EMB总体耐药情况较高,今后须进一步加强耐药结核病的防治及临床用药指导。

Objective To apply international comparability of TB resistant to ethambutol information to evaluate the effect of the current TB control strategies. Methods According to WHO / IUATLD standards, sampling method using 100% of diagnostic centers for culture - positive isolates were separated bacterial type identification and ethambutol （EMB） drug susceptibility testing. Results 1 772 strains were collected and isolated for analysis of myeobacterium tuberculosis, etham- butol resistance rate was 16. 70% , which isolated from the smear positive TB patients the early of 1 175 （66. 14% ） , ethambutol resistance rate was 4. 34% ; 597 strains （33.69%） were isolated from retreatment smear-positive tuberculosis patients,the resistance rate of ethambutol was 11.73%. Conclusion Tuberculosis resistant to ethambutol of Jilin province is higher than that of national average level. It＇ s suggested to further strengthen the prevention and treatment of drug - re- sistant TB.