基于古文献中图版的药用植物巴戟天考证

Textual Research of Medicinal Plants Based on Illustration in Ancient Literature-Morindae Officinalis Radix as an Example

历代医药文献为后人留下了丰富的宝藏,其中古文献中的药用植物图版更是中医药学的精华。以历代文献中的图版作为主要研究对象,是本草研究的重要手段。巴戟天始出《神农本草经》,历代本草都有记载。作为一种常用中药,现今已是"四大南药"之一,大量用于中医临床并出口。古今巴戟天品种基源不同,目前考证学者已经达成共识,对于古代巴戟天的品种的认识,目前有多种说法,各种考证也还没有明确定论。本文从古今巴戟天药材原植物考证出发,着重以历代本草绘图为研究对象,试图解释巴戟天的历史变迁。通过考证和药材市场的调查本文认为,归州巴戟天是现在的葡萄科三叶崖爬藤的地下块根;滁州巴戟天则是开口箭属植物的地下根茎。

Objective：To observe the curative efficacy of Xiaopi Hewei capsules in treating precancerous lesions of gastric carcinoma （PLGC） which belonged to stagnation of liver-qi and stomach-qi,and to investigate its influence on endothelin （ET-1）,gastrin （GAS） and somatostatin （SST）.Method：Sixty-four patients with PLGC were randomly divided into control group （32 cases） and observation group （32 cases） by random number table.Patients in both groups received 20 mg omeprazole magnesium enteric-coated tablets,2 bismuth potassium citrate tablets and 0.25 g clarithromycin tablet twice daily for 2 weeks.Patients in control group added 4 weifu Chun tablets thrice daily,and patients in observation group added 6 Xiaopi Hewei capsules thrice daily for 6 months.Scores of stagnation of liver-qi and stomach-qi were evaluated.Gastroscope and pathology were carried out and scores of atrophy of gastric mucous,degree of intestinal metaplasia and dysplasia were graded.Helicobacter pylori （HP） was detected.The levels of ET-1,GAS and SST were detected before and after treatment.Result：By ordinal data chi-square test,the results of gastroscopy and pathological in observation group were superior to those in control group （P 〈 0.05）.Improvement of gastric mucosa atrophy in both groups was better than before according to chi-square test （P 〈 0.01）,while the observation group obtained better results （P 〈 0.05）.Liver-qi stagnation syndrome score in observation group was less than that in control group at the third and sixth months after treatment （P 〈 0.01）.Scores of intestinal metaplasia or （and） dysplasia in observation group were less than those in control group （P 〈 0.01）.Clearance of HP in control group was 79.2%,while the data in observation group was 84%.There was no significant difference between both groups.Infection rate of Hp in control group was 40%,while the data in observation group was 17.14%.Infection rate in observation group was lower than that in control group after 6-month treatment （P 〈 0.05）.Levels of serum ET-1 and GAS in observation group were less than those in control group,SST level in observation group was higher than those in control group （P 〈 0.01）.Conclusion：Xiaopi Hewei capsules could improve clinical symptoms with PLGC patients （liver-qi stagnation syndrome）,reduce the recurrence of HP.It has certain blocking effect on the progression from PLGC to gastric cancer.Its mechanism may be related to enhancing the serum level of SST and reducing the serum levels of ET-1 and GAS.