血浆NT-proBNP检测在陈旧性心肌梗死中的应用价值

Application value of plasma NT-Pro BNP detection in the old myocardial infarction

目的探讨血浆N末端脑钠肽前体（NT-pro BNP）水平在陈旧性心肌梗死检测中的临床应用价值。方法对2012年4月至2014年4月来该院诊治的80例陈旧性心肌梗死患者的入院资料进行分析,采用胶体金法试剂盒48 h内对患者NT-pro BNP水平进行测定,根据患者血浆NT-pro BNP水平进行分组,≥300 pg/mL为观察组,〈300 pg/mL为对照组,各40例。两组患者均行常规检查,比较两组患者NT-pro BNP平均水平、住院时间、预后等相关指标。结果观察组血浆NT-pro BNP平均水平[（698.20±384.50）pg/mL]高于对照组（48.45±25.26）pg/mL,住院时间[（18.27±6.73）d]长于对照组[（15.52±5.81）d],差异均有统计学意义（P〈0.05）;观察组不良反应发生率为37.50%（15/40）,高于对照组的17.50%（7/40）,差异有统计学意义（P〈0.05）;NT-pro BNP平均水平小于1 500 ng/mL的患者的心血管疾病发生率为10.87%（5/46）,NTpro BNP平均水平为1 500～3 000 ng/mL的患者的心血管疾病发生率为47.37%（9/19）,NT-pro BNP平均水平大于3 000 ng/mL的患者的心血管疾病发生率为73.33%（11/13）。结论 NT-pro BNP的血浆水平是陈旧性心肌梗死患者预后的重要因子,可作为陈旧性心肌梗死的判断因素。

Objective To investigate levels of plasma NT-pro BNP in patients with old myocardial infarction in the clinical application value of detection. Methods The database of 80 patients with old myocardial infarction received by this hospital from April 2013 to April 2014 were analyzed. and divided into the observation group and the control group,40 in each group according to their levels of plasma NT-pro BNP detected by colloidal gold kit. The both groups were conducted routine examination,whose plasma NT-pro BNP concentrations were measured by enzyme linked immunosorbent assay. The mean NT-pro BNP levels,hospitalization time and related indicators of prognosis were compared and analyzed. Results The plasma NT-pro BNP levelsin the observation group[（698.20±384.50）pg/mL] was higher than that of the control group[（48.45±25.26）pg/mL],and hospitalization time[（12.8±6.7）d] was longer than that of the control group[（8.1±6.7）d] with statistically significant differences（P〈0.05）;the incidence of adverse reactions of the observation group[37.50%（15/40）] was lower than that of the control group[17.50%（7/40）],and the difference had statistically significance（P〈0.05）. The occurrence rates of cardiovascular disease in patients with the aver-age level of NT-pro BNP〈1 500 ng/mL,1 500～3 000 ng/mL and〉 3 000 ng/mL were 10.87%（5/46）,47.37%（9/19） and 73.33%（11/13） respectively. Conclusion The plasma concentration of NT-pro BNP is an important factor for the prognosis of patients with old myocardial infarction,which was deemed as one of the judgment factors.