miR-223在乳腺浸润性导管癌中的表达及临床意义

Expression of miR-223 in breast invasive ductal carcinoma and its clinical significance

目的：研究miR-223在乳腺浸润性导管癌中的表达及临床意义。方法：选取2013年1-10月在该院治疗的56例乳腺浸润性导管癌及其周围癌旁组织（距离癌灶〉2 cm）样本和36例乳腺良性病变组织样本进行检测。结果：miR-223在乳腺浸润性导管癌组织中的表达比在乳腺良性病变组织和癌旁组织中的表达更加显著（P〈0.05）;其在癌旁组织及乳腺良性病变组织中的表达比较差异无统计学意义（P〉0.05）;miR-223的表达与TNM分期、淋巴结转移及Her-2表达其呈正相关（P〈0.05）。结论：miR-223在乳腺浸润性导管癌组织中表达的明显高于其他组织,miR-223具有乳腺浸润性导管癌基因的表达特异性,能够成为诊断乳腺浸润性导管癌及判断其预后的标准。

Objective： To study the expression of miR- 223 in breast invasive ductal carcinoma. Methods： Fifty- six samples of breast invasive ductal carcinoma and the surrounding tissues（ the distance from foci 2〉 cm） and thirtysix samples of breast benign lesions treated in the hospital from January to October in 2013 were selected,then the expressions of miR- 223 were detected. Results： The expression of miR- 223 in breast invasive ductal carcinoma was statistically significantly higher than those in breast benign lesions and cancer- adjacent tissues（ P〈0.05）; there was no statistically significant difference in the expression of miR- 223 between cancer- adjacent tissues and breast benign lesions（ P〉0.05）; miR- 223 expression was positively correlated with TNM staging,lymph node metastasis and Her- 2 expression（ P〈0.05）. Conclusion： The expression of miR- 223 in breast invasive ductal carcinoma is significantly higher than those in the other tissues,miR- 223 has specificity of gene expression in breast invasive ductal carcinoma,which can become a criterion for diagnosing breast invasive ductal carcinoma and predicting prognosis.