青翘抗毒方免煎中药颗粒与传统中药煎剂治疗外感风热型感冒疗效比较

Comparison of the Efficacy between Qingqiao Kangdu Decocting-Free Granules and Traditional Decoction in the Treatment of Common Cold with Exogenous Wind-Heat Syndrome

目的比较青翘抗毒方的两种不同剂型(智能免煎中药颗粒制剂与传统中药煎剂)治疗外感风热型感冒的疗效。方法选择60例风热型感冒患者,随机双盲分为治疗组与对照组各30例,对照组予青翘抗毒方传统中药煎剂;治疗组予青翘抗毒方免煎颗粒剂制成的液体剂型。两组患者均每次给药150 ml,每日3次,用药5天后观察两组患者临床疗效。记录两组患者发热、咽痛痊愈情况,并比较两组治疗前后中医证候积分。结果两组治疗后中医证候积分均较本组治疗前明显降低(P<0.01),治疗后组间比较差异无统计学意义(P>0.05)。两组临床疗效总有效率均为100%,两组比较差异无统计学意义(P>0.05)。对照组发热、咽痛症状痊愈率为83.33%,治疗组为80.00%,两组比较差异无统计学意义(P>0.05)。结论青翘抗毒方免煎中药颗粒制剂与传统中药煎剂治疗风热型感冒疗效相当。

Objective To compare efficacy of two different dosage forms of Qingqiao Kangdu formula（ decocting-free granules and traditional decoction） in the treatment of common cold with exogenous wind-heat syndrome.Methods Sixty common cold patients with wind-heat syndrome were then randomly divided into a treatment group and a control group,with 30 cases in each. Qingqiao Kangdu formula was prescribed for both groups. The control group took it using traditional decoction method to cook Chinese medicinal pieces; treatment group took it also in liquid form using decocting-free granules with the same formula and same amout of uncooked medicinals. Patients of two groups were each administered 150 ml medicine,3 times a day for 5 days. The scores of main and secondary symptoms before and after treatment of both groups were recorded and recovery rates of every symptoms were calculated,so as to compare total TCM symptom scores and clinical effective rate of two groups. Results After treatment,total TCM symptom scores of two groups were notedly lower compared within each group before（ P〉0. 01）,while compared with one another after treatment the results showed no statistical significance（ P〈0. 05）. The clinical effective rate of each group was 100%（ P〈0. 05）. Recovery rate of fever and sore throat in the control group was 83. 33%,whereas that of the treatment group was 80. 00%（ P〈0. 05）. Conclusion Qingqiao Kangdu decocting-free granules and traditional decoction have the same efficacy in the treatment of common cold wind-heat syndrome type.