SDF-1、CXCR4在三阴性乳腺癌组织中的表达及其与患者预后的相关性

Expression of SDF-1 and CXCR4 in triple negative breast cancer tissues and its relationship with prognosis

目的探讨基质细胞衍生因子-1（SDF-1）及基质细胞衍生因子受体-4（CXCR4）在三阴性乳腺癌（TNBC）组织中的表达和临床意义。方法用免疫组化法检测77例TNBC组织中SDF-1和CXCR4的表达,分析SDF-1和CXCR4与TNBC临床病理特征及患者预后的关系。结果 SDF-1和CXCR4在TNBC中高表达率分别为41.6%、64.9%,且二者表达呈显著正相关（P=0.041）;SDF-1和CXCR4高表达与患者年龄、肿瘤大小、临床分期及组织学分级不相关（P〉0.05）,与淋巴结转移及无瘤生存呈显著正相关;多因素分析结果表明：SDF-1是TNBC患者无瘤生存的独立预后因素（OR=2.318,95%CI=1.028～5.230）。生存分析显示SDF-1和CXCR4高表达者无瘤生存时间短于低表达者（P均〈0.05）。结论 TNBC中SDF-1/CXCR4表达可作为判断TNBC预后的重要生物学指标。

Objective To investigate the expression and clinical significance of stromal cell derived factor-1（ SDF-1）and its receptor stromal cell derived factor receptor-4（ CXCR4） in triple negative breast cancer（ TNBC） tissue. Methods The expression of SDF-1 and CXCR4 of 77 TNBC cases were detected by using immunohistochemistry. The correlation between SDF-1 / CXCR and clinical pathological features and prognosis were assessed. Results The expression rate of SDF-1 and CXCR4 in TNBC tissues was 41. 6%,64. 9%,respectively. The expression rate of SDF-1 and CXCR4 in TNBC tissues were significantly correlated（ P = 0. 041）. The high expression of SDF-1 and CXCR4 were not correlated with age,tumor size,clinical stage and histological grade（P〉0. 05）,but obviously correlated with lymph node metastasis（ PSDF-1 = 0. 021,PCXCR4 = 0. 010） and disease free survival（ PSDF-1 = 0. 023,PCXCR4 = 0. 015）. COX regression multivariate analysis showed that SDF-1 was an independent prognostic factor of disease free survival in TNBC（ OR = 2. 318,95% CI = 1. 028-5. 230）. Kaplan-Meier survival analysis indicated that time of disease free survival was shorter in SDF-1and CXCR4 high expression patients than that in low expression patients（ PSDF-1 = 0. 011,PCXCR4 = 0. 018）. Conclusions The expression of SDF-1 and CXCR4 in TNBC tissues can be used as important biomarkers of the prognosis.