药源性精神障碍212例文献分析

Document analysis of 212 cases of drug-induced mental disorder

目的:探讨药源性精神障碍发生的特点和规律,为临床安全用药提供参考。方法:检索中文医药卫生期刊1979-2013年报道的药源性精神障碍个案病例,并对文献资料进行整理、汇总和分析。结果:老年人发生比例较高;精神障碍发生在给药24 h后的最多,占66.51%;抗微生物药、精神系统药和心血管系统药导致的精神障碍的发生率位居前3位;药源性精神障碍的发生与性别和给药途径无关。结论:药源性精神障碍的发生与年龄、用药时间、用药剂量和药物作用机制等有关。临床中应根据患者情况调整用药剂量,进行全程监护。

OBJECTIVE To investigate the characteristics of drug-induced mental disorder and provide reference for the drug safety in clinical practice. METHODS The cases of drug-induced mental disorder, published on Chinese medical periodicals during the period of 1979 to 2013, were collected and analyzed. RESULTS The incidence of old people is high. Most mental disorders happened 24 hours after administration,accounting for 66. 51%. The top three incidence of mental disorder were in- duced by antimicrobial drugs, mental drugs and cardiovascular system drugs, respectively. Drug-induced mental disorder was not related to sex or administration route. CONCLUSION Drug-induced mental disorder was related to the age, time of medica- tion, medicine doses and mechanism of drug action. We should adjust the dosages according to the clinical symptoms, and take proper monitoring.