盐酸氨溴索对Stanford A型主动脉夹层急诊手术后的肺保护作用

The lung protection of ambroxol hydrochloride after emergency operation for stanford type A aortic dissection

Stanford A型主动脉夹层是临床上较为常见的致命性事件,死亡率高。快速诊断和急诊手术对于改善患者生存率具有重要意义。急诊行近端主动脉置换术的术后肺部并发症发生率很高,严重影响患者术后的康复。盐酸氨溴索因其独特的肺保护和抗炎抗氧化作用,及不良反应少、在肺部分布容积高等特点现已常规用于近端主动脉置换术急诊手术的术后。然而,目前国内外尚没有相关的大规模临床试验为术后盐酸氨溴索的使用提供有力的依据,且其使用剂量及用药疗程仍存在争议。现就盐酸氨溴索在围手术期的应用进行文献综述,并根据其作用机制及作用特点,为其大剂量使用合理性提供参考。

Stanford type A aortic dissection is a common fatal clinical event with high mortality. Rapid diagnosis and emer- gency surgery is important to improve survivals. Postoperative pulmonary complications of emergency proximal aortic replace- ment surgery are of high incidence, which severely affects the prognosis. Ambroxol hydrochloride has been routinely used for emergency proximal aortic replacement surgery, owing to the characteristics such as lung protection profile, antioxidant and an- ti-inflarnatory effects, few adverse reactions, and high volume of distribution in the lung. However, there are no large-scale clinical trials to provide a strong basis for the use of ambroxol hydrochloride postoperatively at present. We reviewed pertinent literature in order to provide references for the rational application.