地佐辛防止全凭七氟醚麻醉术后躁动临床报告

Clinicl report of dezocine in preventing the postoperative restlessness of anesthesia with sevoflurane

目的观察地佐辛预防全凭七氟醚麻醉苏醒期躁动的效果。方法选择美国麻醉师协会I-Ⅱ级择期手术患者40例,随机分为观察组和对照组,每组20例。两组以七氟醚维持麻醉,观察组患者于手术结束前30 min给予静脉注射地佐辛注射液0.1 mg/kg,对照组患者则接受七氟醚维持麻醉。结果观察组全身麻醉苏醒期Ramsay、VAS镇静评分明显低于对照组,差异有统计学意义（P均〈0.05）;两组患者的呼吸恢复、睁眼、拔管时间比较差异均无统计学意义（P〉0.05）。结论地佐辛可有效预防或降低七氟醚全身麻醉苏醒期兴奋躁动的发生,采用0.1 mg/kg剂量时苏醒质量好,无明显不良反应。

Objective To observe the effect of dezocine on preventing agitation in anesthesia with sevoflurane.Methods Forty patients of American Society of Anesthesiologists（ ASA） I-II undergoing elective surgery were randomly divided into two groups： observation group and control group,with 20 cases in each group. Patients in the two groups were given sevoflurane anesthesia. The observation group was given intravenous injection of dezocine 0. 1 mg / kg 30 minutes before the end of operation and patients in the control group received routine drug anesthesia. Results The incidence of Ramsay,VAS score were significantly lower than those of the control group,and the differences were statistically significant（ P〉0. 05）. Between the two groups,the breathing recovery time,eyes open time and extubation time were not statistically different（ P〈0. 05）. Conclusion Dezocine can be effective on preventing or reducing the exciting and restlessness of patients recovery from general sevoflurane anesthesia. The dosage of 0. 1 mg / kg has good quality and no obvious adverse reactions.