糖尿病周围神经损害特征分析

Analysis of the characteristics of diabetes peripheral neuropathy

目的探讨糖尿病周围神经损害(DPN)的特点以及相关危险因素。方法选择2011年8月至2013年8月糖尿病周围神经病变患者100例,根据神经传导速度将患者分为DPN组和无DPN组,比较两组神经功能及相关因素。结果病程、年龄是DPN发生的危险因素,收缩压、空腹血糖、总胆固醇、三酰甘油与DPN呈正相关,但差异无统计学意义(P>0.05)。细有髓鞘神经纤维、粗有髓鞘神经纤维病变组高密度脂蛋白胆固醇水平下降(P<0.05),而且下肢细有髓鞘神经纤维是DPN的好发部位。结论糖尿病患者随着年龄的增加、病程时间的增长,DPN危险系数将不断增加,高密度脂蛋白胆固醇与DPN发生发展密切相关。

Objective To investigate the characteristics of peripheral nerve damage in diabetes and related risk factors.Methods From August 2011 to August 2013,100 cases of diabetes peripheral neuropathy were selected according to the nerve conduction velocity,the patients were divided into DPN group and non DPN group. The nerve functions and correlation factor were compared between the two groups. Results The course of disease,age were risk factors of DPN,SBP,FPG,total cholesterol（ TG）,triglyceride（ TC） was positively correlated with DPN,but the difference was not statistically significant（ P〉0. 05）. HDL-C levels fine myelinated nerve fiber and coarse myelin ted nerve fibers damage group were decreased（ P〈0. 05）,and lower extremity fine myelinated nervefibers are sites of DPN. Conclusion Patients with diabetes increases with age,duration of growth,DPN will increase the risk coefficient,HDL-C is closely related with the occurrence and development of DPN.