肾气亏虚型OA未病临床诊断试验的初步研究

Preliminary study on disease clinical diagnostic test on OA with the kidney qi deficiency type

目的:研究骨性关节炎(OA)患者尿液中Ⅱ型胶原C-端肽(CTX-Ⅱ)、血清中软骨寡聚基质蛋白(COMP)水平与病变严重程度的相关性,探讨其作为OA早期诊断及病情评估指标的价值和意义。方法:采用ELISA方法测定OA患者、类风湿关节炎患者及同期确诊的健康人的尿液中CTX-Ⅱ和血清中COMP水平。结果:与健康人群组比较,肾气亏虚型OA未病组与肾气亏虚型OA已病组CTX-Ⅱ含量增加,差异有统计学意义;肾气亏虚型OA未病组、肾气亏虚型OA已病组与类风湿关节炎患者组COMP含量增加,差异有统计学意义。结论:CTX-Ⅱ和COMP可作为OA辅助检查指标用于OA的早期诊断。

Objective： Investigating the correlation between the levels which of CTX-Ⅱ in urine and COMP in serum and severity of osteoarthritis, to explore the value and significance of the early diagnosis of OA. Methods ： The levels of CTX- Ⅱ and COMP in urine were analyzed by enzyme-linked immunosorbent assay （ELISA） in patients with OA, RF and healthy people. Results ：① CTX - Ⅱ levels between groups compared with the healthy group ： The group of kidney deficiency of the latent OA significant difference; The group of kidney deficiency of OA significant difference;② COMP levels between groups compared with the healthy group ： The group of kidney deficiency of the latent OA significant difference ; The group of kidney deficiency of OA significant difference; The group of rheumatoid arthritis significant difference. Conclusion ： CTX - Ⅱ and COMP can be used as OA auxiliary examination index for early diagnosis of osteoarthritis （ OA ） , should be closely combined with clinical and other inspection, and rule out other diseases, in order to make the correct diagnosis.