内源性大麻素系统对神经系统保护作用的研究进展

Progress in research on the protective role of ECS in nervous system

内源性大麻素系统(endocannabinoid system,ECS)主要包括G蛋白耦联受体CB1、CB2、内源性配基AEA、2-AG及内源性配基的失活系统FAAH等。在中枢神经系统中,ECS可通过抗炎、抗氧化、调节神经递质的释放、抑制钙离子浓度等机制发挥神经保护作用,具备广泛的生理保护作用及临床应用价值。本文根据现有研究报道对内源性大麻素系统的神经保护作用进行综述。

The endogenous cannabinoid system（endocannabinoidsystem,ECS）consists primarily of G protein-coupled receptor CB1,CB2,endogenous ligands for AEA,2-AG and inactivation system AEA hydrolysis enzymes system（FAAH）. Numerous studies have shown that the endogenous cannabinoid system can play a neuroprotective role via complex mechanisms,such as the anti-inflammatory,antioxidant,regulation of neurotransmitter release,inhibition of calcium ion concentration and so on. This article is to review the protective function of ECS in nervous system.