期刊文献+

核苷类似物治疗儿童朗格罕细胞组织细胞增生症

下载PDF
导出
摘要 朗格罕细胞组织细胞增生症(Langerhans cell histiocytosis,LCH)是一组由朗格罕细胞为主的组织细胞在机体网状内皮系统内广泛增生、浸润为基本特征的疾病,全身各器官、系统均可受累,其中肝、脾、血液系统和肺被认为是受累的危险器官[1]。LCH的异质性很强,单系统和(或)无危险器官受累患儿对常规治疗反应好,个别甚至可自愈,长期生存率在90%以上,而多系统尤其伴危险器官受累的高危患儿对常规化疗反应不佳,成为难治或复发病例,预后不良[2]。近些年,陆续报道了核苷类似物对难治和复发LCH患者的挽救治疗及一线治疗,效果令人振奋。本文就此方面进展进行综述。
出处 《中国小儿血液与肿瘤杂志》 CAS 2014年第6期283-286,共4页 Journal of China Pediatric Blood and Cancer
  • 相关文献

参考文献20

  • 1Abla O,Egeler RM,Weitzman S.Langerhans cell histiocytosis:current concepts and treatments.Cancer Treat Rev,2010,36:354-359.
  • 2Kim BE,Koh KN,Suh JK.Clinical features and treatment outcomes of Langerhans cell histiocytosis:a nationwide survey from Korea histiocytosis working party.J Pediatr Hematol Oncol,2014,36:125-133.
  • 3Zenhusern R,Schmitz SF,Solenthaler M,et al.Randomized trial of daily versus weekly administration of 2-chlorodeoxyadenosine in patients with hairy cell leukemia:a multicenter phaseⅢtrial(SAKK32/98).Leuk Lymphoma,2009,50:1501-1511.
  • 4Kalinka-Warzocha E,Wajs J,Lech-Maranda E,et al.Polish Lymphoma Research Group.Randomized comparison of cladribine alone or in combination with cyclophosphamide,and cyclophosphamide,vincristine and prednisone in previously untreated low-grade B-cell non-Hodgkin lymphoma patients.Final report of the Polish Lymphoma Research Group.Cancer,2008,113:367-375.
  • 5Holowiecki J,Grosicki S,Giebel S,et al.Cladribine,but not fludarabinr,added to daunorubicin and cytarabine during induction prolongs survival of patients with acute myeloid leukemia:a multicenter,randomized phaseⅢstudy..J Clin Oncol,2012,30:2441-2448.
  • 6Minkov M,Steiner M,Potschger U.Reactivations in multisystem Langerhans cell histiocytosis:data of the international LCH registry.J Pediatr,2008,153:700-705.
  • 7Saven A,Figueroa ML,Piro LD,et al.2-Chlorodeoxyadenosine to Treat Refractory Histiocytosis X.N Engl J Med,1993,329:734-735.
  • 8Stine KC,Saylors RL,Williams LL,et al.2-Chlorodeoxyadenosine(2-CDA)for the treatment of refractory or recurrent Langerhans cell histiocytosis(LCH)in pediatric patients.Med Pediater Oncol,1997,29:288-292.
  • 9Weitzman S,Wayne AS,Arceci R,et al.Nucleoside analogues in the therapy of Langerhans cell histiocytosis:a survey of members of the histiocyte society and review of the literature.Med Pediatr Oncol,1999,33:476-481.
  • 10Saven A and Burian C.Cladribine activity in adult Langerhans-cell histiocytisis.Blood,1999,93:4125-4130.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部