NLRP3炎症小体与糖尿病

NLRP3 Inflammasome and Diabetes

目前,糖尿病已成为全球化的流行性疾病,其慢性进行性病程和多种急慢性并发症,严重影响着患者的生活质量,因此提高糖尿病的防治水平是近年的研究热点。NOD样受体家族的NLRP3炎症小体能感受代谢应激信号的刺激,导致天冬半胱氨酸酶-1(caspase-1)活化和白介素1β(IL-1β)产生,与糖尿病的发生发展密切相关。新近研究表明,NLRP3炎症小体可能是治疗糖尿病潜在的新靶点。本文将对NLRP3炎症小体的活化与调控机制、对糖代谢的影响以及针对性的靶向治疗进行综述。

Diabetes has become a global epidemic disease now. Its chronic progressive deterioration and the acute and chronic complications affect the quality of the patients＇ lives seriously. The prevention and treatment of diabetes has become one of the research focuses in recent years. NLRP3 （NOD-like receptor family, pyrin domain containing 3） inflammasome can recognize the metabolic stress signals, and cause caspase-1 activation and interleukin-1β （IL-1β） production, and is closely related to diabetes development. The latest studies have shown that NLRP3 inflammasome will be a new potential target for the treatment of diabetes. This article reviews the activation and regulation of NL- RP3 inflammasome, and the effect of NLRP3 inflammasome on glucose metabolism and its targeted therapy in diabe- tes.