甲状腺髓样癌中Ki67和降钙素的表达及临床意义

Expression and clinical significance of Ki67 and calcitonin in medullary thyroid carcinoma

目的:探讨增殖细胞相关抗原(Ki67)和降钙素在甲状腺髓样癌组织中的表达及其临床意义。方法:采用免疫组织化学SP法分别检测44例甲状腺髓样癌组织和20例癌旁组织中Ki67和降钙素的表达水平。结果:44例甲状腺髓样癌组织中Ki67和降钙素的表达率为86.36%(38/44)和100.00%(44/44),明显高于其在癌旁组织中的表达率0%(0/20)和20%(4/20)(P<0.01)。Ki67增殖指数和降钙素与患者肿瘤大小、临床分期和淋巴结转移有关(P<0.05),而与患者年龄、性别无关(P>0.05)。在甲状腺髓样癌中Ki67和降钙素的表达水平无显著相关性(P=0.081)。结论:Ki67和降钙素高表达与甲状腺髓样癌的发生、发展及浸润转移有关,可作为判断甲状腺髓样癌生物学行为的重要指标。

Objective：To investigate the expression and clinical significance of Ki67 and calcitonin in medullary thyroid carcinoma（MTC）. Method：The expression level of Ki67 and calcitonin was studied in 44 cases of medullary thyroid carcinoma tissue and 20 cases of adjacent nontumor tissue by SP immunohistochemistry. Result：The posi- tive expression of Ki67 and caleitonin in medullary thyroid carcinoma tissue were 86.36% （38/44） and 100.00% （44/44） respectively. There was a significant difference between carcinoma and normal thyroid tissue （P〈0.01）. The overexpression of Ki67 and calcitonin in medullary thyroid carcinoma had no relationship with gender and age of patients, but had relationship with size of tumor,clinical staging and lymph node metastasis （P〈0.05）. Mean- while, Ki67 and calcitonon had no significant correlation with each other. Conclusion：The overexpression of Ki67 and ealcitonin may play important role in occurrence, development and metastasis of medullary thyroid carcinoma. It may be used as an important judgement for the biological behavior of medullary thyroid carcinoma.