期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肠道微生态与肠道免疫相互作用的研究进展 被引量：6

原文传递
导出
摘要 人体肠道拥有丰富的微生态系统,内含100多万亿以上的微生物,种类多达1 000余种,占人体微生物总量的78％左右.肠道菌群被称为人体的“新器官”,在机体免疫反应、新陈代谢以及疾病发生发展等生理、病理过程中起重要作用,肠道微生态失衡与多种临床疾病相关.正常肠黏膜屏障由机械屏障、化学屏障、免疫屏障以及生物屏障共同构成,可有效防止肠内有害物质如细菌和毒素穿过肠黏膜进入人体.
作者 岳意茹 王俊平 刘萍 董丽娜
机构地区 山西医科大学附属人民医院消化科 山西省人民医院消化科 山西省人民医院妇产科 山西省人民医院中心实验室
出处 《中华内科杂志》 CAS CSCD 北大核心 2014年第12期988-991,共4页 Chinese Journal of Internal Medicine
基金 山西省国际科技合作项目（2013081066） 山西省卫生厅攻关科研项目（201201059）
关键词 肠道微生态失衡 相互作用 肠道免疫 人体微生物 肠黏膜屏障 机体免疫反应 机械屏障 临床疾病
分类号 R333 [医药卫生—人体生理学]
  • 相关文献

参考文献30

  • 1Kelsall B.Recent progress in understanding the phenotype and function of intestinal dendritic cells and macrophages[J].Mucosal Immunol,2008,1:460-469.
  • 2Macpherson A J,Uhr T.Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria[J].Science,2004,303:1662-1665.
  • 3Salzman NH,Ghosh D,Huttner KM,et al.Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin[J].Nature,2003,422:522-526.
  • 4Garrett WS,Lord GM,Punit S,et al.Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system[J].Cell,2007,131:33-45.
  • 5Vijay-Kumar M,Aitken JD,Carvalho FA,et al.Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor5[J].Science,2010,328:228-231.
  • 6Elinav E,Strowig T,Kau AL,et al.NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis[J].Cell,2011,145:745-757.
  • 7Hepworth MR,Monticelli LA,Fung TC,et al.Innate lymphoid cells regulate CD + 4 T-cell responses to intestinal commensal bacteria[J].Nature,2013,498:113-117.
  • 8Chase CC,Hurley DJ,Reber AJ.Neonatal immune development in the calf and its impact on vaccine response[J].Vet Clin North Am Food Anim Pract,2008,24:87-104.
  • 9Okada H,Kuhn C,Feillet H,et al.The ‘ hygiene hypothesis’ for autoimmune and allergic diseases:an update[J].Clin Exp Immunol,2010,160:1-9.
  • 10Olszak T,An D,Zeissig S,et al.Microbial exposure during early life has persistent effects on natural killer T cell function[J].Science,2012,336:489-493.

二级参考文献16

  • 1Ivanov AI, Nusrat A, Parkos CA. The epithelium in inflammatory bowel disease: potential role of endocytosis of junctional proteins in barrier disruption. Novartis Found Syrup, 2004,263 : 115-124.
  • 2Heller F, Florian P, Bojarski C, et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology, 2005, 129 : 550-564.
  • 3Bruewer M, Samarin S, Nusrat A. Inflammatory bowel disease and the apical junctional complex. Ann N Y Acad Sci, 2006,1072 : 242-252.
  • 4Wehkamp J, Harder J, Weichenthal M,et al. NOD2 (CARD15) mutations in Crohn' s disease are associated with diminished mucosal alpha-defensin expression. Gut, 2004, 53:1658-1664.
  • 5Fahlgren A, Hammarstrom S, Danielsson A,et al. beta-Defensin- 3 and-4 in intestinal epithelial cells display increased mRNA expression in ulcerative colitis. Clin Exp Immunol, 2004, 137: 379-385.
  • 6Gibson PR, Muir JG. Reinforcing the mucus: a new therapeutic approach for ulcerative colitis? Gut,2005, 54:900-903.
  • 7Ehehalt R, Wagenblast J, Erben G, et al. Phosphatidylcholine and lysophosphatidylcholine in intestinal mucus of ulcerative colitis patients. A quantitative approach by nanoelectrospray tandem mass spectrometry. Stand J Gastroenterol,2004 ,39 :737-742.
  • 8Yeung MM, Melgar S, Baranov V, et al. Characterisation of mucosal lymphoid aggregates in ulcerative colitis: immune cell phenotype and TcR-gammadelta expression. Gut, 2000,47 : 215- 227.
  • 9Mudter J, Neurath MF. Apoptosis of T cells and the control of inflammatory bowel disease : therapeutic implications Gut, 2007, 56:293-303.
  • 10Yen D, Cheung J, Scheerens H, et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J ClinInvest, 2006,116:1310-1316.

同被引文献59

  • 1李润美,韩英,王继恒,王志红.炎症性肠病患者肠道菌丛结构特征的指纹图谱分析[J].中华内科杂志,2007,46(2):96-98. 被引量：10
  • 2武庆斌,郑跃杰,黄永坤.儿童肠道菌群-基础与临床[M].北京:科学出版社,2012:6.
  • 3Mondot S,de Wouters T,DoréJ,et al.The human gut microbiome and its dysfunctions[J].Dig Dis,2013,31(3/4):278-285.
  • 4Ling Z,Liu X,Luo Y,et al.Pyrosequencing analysis of the human microbiota of healthy Chinese undergraduates[J].BMC Genomics,2013,14:390.
  • 5Ashraf R,Shah NP.Selective and differential enumerations of Lactobacillus delbrueckii subsp.bulgaricus,Streptococcus thermophilus,Lactobacillus acidophilus,Lactobacillus casei and Bifidobacterium spp.in yoghurt-a review[J].Int J Food Microbiol,2011,149(3):194-208.
  • 6Liévin-Le,Moal V,Servin AL.Anti-infective activities of lactobacillus strains in the human intestinal microbiota:from probiotics to gastrointestinal anti-infectious biotherapeutic agents[J].Clin Microbiol Rev,2014,27(2):167-199.
  • 7Kumar A,Alrefai WA,Borthakur A,et al.Lactobacillus acidophilus counteracts enteropathogenic E.coli-induced inhibition of butyrate uptake in intestinal epithelial cells[J].Am J Physiol Gastrointest Liver Physiol,2015,309(7):602-607.
  • 8German JB,Freeman SL,Lebrilla CB,et al.Human milk oligosaccharides:evolution,structures and bioselectivity as substrates for intestinal bacteria[J].Nestle Nutr Workshop Ser Pediatr Program,2008,62:205-218.
  • 9Markle JG,Frank DN,Mortin-Toth S,et al.Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity[J].Science,2013,339(6123):1084-1088.
  • 10李东,孙永明,张宇,袁振宏,许敬亮,李连华.城市生活垃圾厌氧消化处理技术的应用研究进展[J].生物质化学工程,2008,42(4):43-50. 被引量：19

引证文献6

二级引证文献54

中华内科杂志
2014年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部