乳腺癌易感基因1、2在散发性乳腺癌中的表达及意义

Significance and expressions of BRCA1 and BRCA2 protein in sporadic breast cancer

目的：探讨乳腺癌易感基因1（ BRCA1）和乳腺癌易感基因2（ BRCA2）蛋白表达在散发性乳腺癌中的作用。方法收集86例乳腺癌及癌旁组织、48例乳腺增生症手术标本，采用免疫组织化学S－P法检测BRCA1及BRCA2蛋白在各例中的表达情况。结果 BRCA1表达在乳腺癌、乳腺癌旁组织、乳腺增生症中的阳性率分别为60．5％（52／86）、46．5％（40／86）和100％（48／48），3组间比较，差异有统计学意义（ P＜0．01）。 BRCA2表达在乳腺癌、乳腺癌旁组织、乳腺增生症中的阳性率分别为41．9％（36／86）、55．8％（48／86）和95．8％（46／48），3组间比较，差异有统计学意义（ P ＜0．01）。乳腺癌组织中BRCA1与BRCA2蛋白表达之间无显著性相关（ r＝0．673，P＞0．05）。结论BRCA1和BRCA2蛋白异常表达在散发性乳腺癌发生、发展过程中起着一定作用。

Objective To explore the role of expressions of BRCA 1 and BRCA2 protein in sporadic breast cancer.Methods Eighty-six cases of breast cancer and adjacent cancer tissues and 48 cases of breast hyperplasia surgical specimens were collected . And the immunohistochemical S-P method was employed for detecting the protein expressions of BRCA 1 and BRCA2.Results BRCA1 expression in breast cancer, breast cancer adjacent cancer tissues and positive rates in breast hyperplasia were 60.5%（52/86）, 46.5%（ 40/86 ） and 100%（ 48/48 ） .The difference was significant among three groups .The BRCA2 expression in breast cancer , breast cancer adjacent cancer tissues and positive rates in breast hyperplasia were 41.9%（ 36/86 ） , 55.8%（ 48/86 ） and 95.8%（ 46/48 ） respectively. And the difference was significant among three groups .The expression of BRCA1 had no obvious relation with BRCA 2 protein in breast cancer tissues （r=0.673, P〉0.05）.Conclusion The aberrant expressions of BRCA1 and BRCA2 protein plays a major role in the occurrence and progression of sporadic breast cancer .