周细胞在泌尿生殖系统中的作用

Roles of pericytes in the urological and reproductive systems

周细胞又称为壁细胞、Rouget细胞,是构成微血管壁的主要细胞之一。它不仅对血管的成熟、稳定及功能的维持起重要作用,同时也在机体各组织器官的生长发育、创伤修复等生理病理过程中发挥重要作用。周细胞功能的研究主要集中在细胞多能性、血管功能调节、纤维化过程等方面,在泌尿外科学领域主要表现在肾纤维化、肾血流调节、肾小球滤过等,而男科学领域的相关研究较欠缺。本文就周细胞的定位和来源、分布及形态、细胞标志物和功能等进行综述,为男科学领域周细胞的进一步研究指明方向。

Pericyte, also known as mural cell or Rouget cell, is one of the main cells that make up the wall of capillaries. Pericytes play important roles not only in the maturation, stability, and function maintenance of blood vessels, but also in the growth and development of tissues and organs, wound repair, and other physiological and pathologibal processes. Researches on the functions of pericytes are mainly concentrated on their multipotency, adjustment of vascular functions, and process of fibrosis, as well as on renal fibrosis, renal blood flow regulation, and glomertilar filtration in urology, but are quite insufficient in andrology. This article reviews the location, origin, distribution, morphology, markers, and functions of pericytes, aiming to induce further studies of pericytes in andrology.