糖尿病与非肌层浸润性膀胱癌预后的关系(附225例报告)

Impact of diabetes mellitus on recurrence and progression in non-muscle-invasive bladder cancer(Report of 225 cases)

目的：探讨糖尿病与非肌层浸润性膀胱癌（non-muscle-invasive bladder cancer,NMIBC）预后的关系。方法：筛选2007年1月~2011年12月在本院因NMIBC施行手术的患者共225例,按一定标准分成糖尿病组（58例）和非糖尿病组（167例）。采用Kaplan-Meier法制作生存曲线,采用COX回归模型分析糖尿病与NMIBC的无复发生存（recurrence-free survival,RFS）和无进展生存（progression-free survival,PFS）的关系。结果：225例患者中,糖尿病患者占25.8%。平均随访56.8（4~83）个月,其中复发91例（40.4%）,进展19例（8.4%）。多因素COX生存分析显示糖尿病和更高的NMIBC复发风险相关,P=0.005,Hazard ratio（HR）=1.87,95%置信区间（CI,confidence interval）为1.21~2.88。结论：糖尿病是NMIBC患者RFS的独立危险因素。

Objective：To investigate the association between diabetes mellitus（DM）and prognosis of non-muscle-invasive bladder cancer（NMIBC）.Method：We retrospectively selected 225 patients with NMIBC treated in our hospital and divided them into DM group and non-DM group.Kaplan-Meier methods were used to make survival curves.Cox regression models were used to analyse the association between DM and recurrence-free survival（RFS）and progression-free survival（PFS）of NMIBC.Result：Of 225 patients,58had DM（25.8%）.Over an median follow-up period of 56.8（range,4-83）months,91（40.4%）patients experienced recurrence and 19（8.4%）patients experienced progression.Multivariable Cox regression analyses showed that DM is associated with a higher risk of recurrence,P=0.005,hazard ratio（HR）=1.87,95% confidence interval（CI）1.21-2.88.Conclusion：DM is an independent predictor of RFS in NMIBC patients.