引导组织再生膜促进兔下颌骨牵张成骨的实验研究

Experimental study on the guided tissue regeneration membrane promoting bone formation in rabbit mandibular distraction osteogenesis

目的 :探讨引导组织再生膜(GTRM)对兔下颌骨牵张成骨新骨形成的促进作用。方法 :将20只新西兰大白兔随机分为2组,每组10只,建立兔下颌骨牵张成骨模型,A组单纯单侧下颌骨牵张成骨;B组将GTRM固定于牵张器内侧行单侧下颌骨牵张成骨。分别于固定期第2、6周时随机处死半数动物获取标本,通过X线、骨组织形态计量学比较2组牵张间隙内成骨效果。采用SPSS11.0软件包对数据进行两样本均数t检验。结果:通过X线及骨组织形态计量学检查并经过统计学分析发现,在固定期第2周和6周时,B组牵张区域内成骨质量显著好于A组(P<0.05)。结论:引导组织再生膜能有效促进兔下颌骨牵张成骨区域新骨的形成。

PURPOSE： To investigate the promotive effect of guided tissue regeneration membrane （GTRM） in rabbit mandibular distraction osteogenesis （DO）. METHODS： Twenty New Zealand＇s white rabbits were randomly divided into 2 groups with ten in each, and then mandibular distraction osteogenesis model in rabbits was established. In group A, only DO was performed on one side of the mandible; in group B, the distraction device was positioned and fixed on the mandible with GTRM inside wrapped around the distraction zone. Half of the animals randomly chosen from each group were sacrificed at the end of week 2 and 6 throughout the consolidation phase. The mandibular samples were taken out for X-ray and histologic examinations. The data was analyzed with SPSS 11.0 software package. RESULTS： Radiological and histological study confirmed that group B showed better bone formation than group A （P〈0.05） at the end of 2nd and 6th week consolidation. CONCLUSION： GTRM could effectively promote bone regeneration in rabbit mandibular DO.