剪切波弹性成像模量值与桥本甲状腺炎临床表现的相关性研究

Correlation of shear wave elastography Young's modulus with different clinical manifestations of Hashimoto's thyroiditis

目的探讨剪切波弹性成像杨氏模量值与桥本甲状腺炎(HT)不同临床表现的相关性。方法将收集的86例临床确诊为HT的患者按照甲状腺功能分成甲亢组、甲功正常组、亚临床甲减组和临床甲减组,应用超声剪切波弹性成像技术,对各组进行超声剪切波弹性量化检测,用方差分析比较各组HT患者甲状腺组织剪切波模量值之间的关系。结果甲亢组、甲功正常组、亚临床甲减组和临床甲减组的HT患者甲状腺组织剪切波弹性模量值依次增大,分别为(15.543±4.319)kPa、(20.083±5.444)kPa、(26.682±5.676)kPa、(29.210±8.848)kPa,组间差异有统计学意义(F=14.925,P<0.01)。HT甲亢组剪切波弹性模量值低于HT甲功正常组、HT亚临床甲减组、HT临床甲减组,差异均有统计学意义(P均<0.05)。HT甲功正常组剪切波弹性模量值低于HT亚临床甲减组、HT临床甲减组,差异有统计学意义(P均<0.05)。结论剪切波弹性成像杨氏模量值与桥本甲状腺炎不同时期的临床表现有一定相关性,可为HT的治疗提供一定的参考信息。

Objective To investigate shear wave elastography Young＇s modulus and correlation Hashimoto＇s thyroiditis （HT） with different clinical manifestations .Methods We divided the 86 cases ,which were clinically diagnosed with HT according to the thyroid function ,into the hyperthyroidism group ,the normal thyroid function group ,the subclinical hy‐pothyroidism group ,and the clinical hypothyroidism group .Using ultrasonic shear wave elastography ,we tested each group to get a elastic modulus .Using analysis of variance ,we compared the relationship of each group’s elastic modulus result .Results The elastic modulus of each group increased successively in hyperthyroidism group ,the normal thyroid function group ,subclinical hypothyroidism group and the clinical hypothyroidism group ,which were seperately （15 .543 ± 4 .319） kPa ,（20.083 ± 5 .444） kPa ,（26 .682 ± 5 .676） kPa ,（29 .210 ± 8 .848） kPa .There were significant differences be‐tween groups .（ F=14 .925 ,P 〈0 .01） .The elastic modulus in hyperthyroidism group was lower than the normal thy‐roid function group ,the subclinical hypothyroidism group and the clinical hypothyroidism group .The differences were sta‐tistically significant （ P 〈0 .05） .The elastic modulus in the normal thyroid function group was lower than the subclinical hypothyroidism group and the clinical hypothyroidism group .The differences were statistically significant （ P 〈 0 .05） . Conclusion The shear wave elastography Young＇s modulus have some relevance ,with the clinical manifestations in differ‐ent periods of Hashimoto＇s thyroiditis ,which can provide a reference for the treatment of HT .