中老年人群同型半胱氨酸分布特点及其健康教育

A review of serum homocysteine levels of middle-aged and elderly people and measures for health education to counter HHcy

目的了解某炼化公司中老年人群血清同型半胱氨酸(homocysteine,Hcy)分布特点,为该地区高同型半胱氨酸血症(hyperhomocysteinemia,HHcy)人群提供健康教育对策。方法整理5113名某炼化公司40岁以上人群体检资料,分析不同性别、年龄段血清Hcy水平和HHcy检出率及与传统心血管疾病主要危险因素的相关关系。结果某炼化公司40岁以上中老年人群的血清Hcy水平为(11.52±7.6)μmol/L,各年龄段男性血清Hcy水平及HHcy检出率均高于女性(P<0.05);同性别年龄组之间HHcy检出率随年龄的增加呈增高趋势;男性、年龄、收缩压、体质量指数、高血压病和肌酐清除率与HHcy存在相关性(P<0.05)。结论某炼化公司40岁以上中老年人群的血清Hcy水平存在有性别与年龄的差异,男性、年龄、收缩压、体质量指数、肌酐清除率和高血压病史是HHcy的危险因素。男性40岁、女性60岁以上人群是本地区实施HHcy健康教育的目标人群。

Objective To obtain the information of the levels of serum homocysteine of the middle-aged and elderly people from a community of Ningbo City, so as to formulate effective health education scheme to counter the disease of hyperhomocysteinemia （HHey）. Method The physical check-up information of 5113 employees over 40 years of age from a local company was obtained and analyzed. The serum Hcy levels and HHcy detection rates were analyzed for different gender and age groups. The correlation between HHey and major traditional risk factors contributing to cardiovascular diseases were also analyzed. Findings The serum Hey levels and HHcy detection rates were both higher in male subjects than in female subjects for all age groups. For subjects within the same gender group, HHcy detection rate increased significantly with age. Male gender, age, systolic pressure, body mass index, history of hypertension and creatinine clearance were found to be correlated with HHcy （p 〈 0.05）. Conclusion A clear difference in serum Hcy level was present in different gender and age groups among middle-aged and elderly population over 40-year-old in the refining and chemical company investigated. Male gender, age, systolic pressure, body mass index, history of hypertension and creatinine clearance were all risk factors for HHey. Men over 40 and women over 60 years of age should be the targeted group for HHey health education.