络合萃取法处理金刚烷胺制药废水

Treatment of Amantadine Pharmaceutical Wastewater by Complexation Extraction

采用络合萃取法处理金刚烷胺制药废水,考察了初始pH、络合剂种类、稀释剂配比、油/水相比和反应温度等对废水中金刚烷胺萃取效率的影响,并对萃取剂中金刚烷胺进行了反萃取分离回收.结果表明:采用V(P204)〔P204为二(2-乙基己基磷酸)〕∶V(正辛醇)为3∶2的复配萃取剂处理金刚烷胺制药废水,在初始pH为8.0、油/水相比为1∶1和温度为25℃的条件下,能够去除废水中99.7%以上的金刚烷胺;在反萃取过程中,V(P204)∶V(正辛醇)为1∶4的复配萃取剂可以获得更高的反萃取效率,以1.0mol/L的HCl溶液为反萃取剂,当油/水相比为1∶1时,可将51.7%的金刚烷胺从萃取剂中反萃分离,回收得到的金刚烷胺盐酸盐溶液可以回用到生产工艺中,P204-正辛醇复配萃取剂可在萃取和反萃取过程中多次重复使用.

For pollution control of amantadine pharmaceutical wastewater and for resource recovery, complexation extraction process was employed to treat the amantadine wastewater. The influences of initial pH value, type of diluents, extractant composition, oil-to-water ratio and temperature on amantadine extraction efficiency were investigated, and the amantadine in extractant was recovered by back- extraction. The results showed that the extraction efficiency of amantadine was above 99. 7% under the conditions of initial pH value 8.0, oil-to-water ratio 1 ： 1 and temperature 25 ~C by using P2o4-octanol ratio 3 ： 2 complex extractant. In the process of back-extraction, Peo4- octanol ratio 1 ： 4 octanol complex extraetant could achieve higher back-extraction efficiency. HC1 solution of 1.0 mol/L was used as stripping agent, and with the oil-to-water ratio of 1 ： 1, about 51.7% amantadine was stripped from the loaded solvent. The recycled amantadine hydrochloride solution could be reused in the amantadine production process. P204-oetanol complexation extractant could be used repeatedly in the extraction and back-extraction processes. The results showed that complexation extraction is a feasible process for amantadine wastewater treatment, which can realize both pollution control and resource recovery.