AECOPD患者入院初始血糖与气道炎症和预后的关系

Relationship of Initial Blood Glucose and Lung Inflammation and Disease Prognosis in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的:探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者入院后初始血糖的水平,并分析其与肺部炎症及预后的关系。方法:根据肺功能将58例AECOPD患者分为轻度组25例、中度组18例和重度组15例,入院后进行肺功能检查、立即抽取随机静脉血及第2天清晨空腹静脉血检查血糖。并对各组患者进行为期6个月的随访,了解患者肺功能情况。结果:空腹血糖水平在中度组、重度组明显升高,在轻度组未见明显异常,且6个月后随访血糖水平较高者,肺功能下降更快。入院后患者随机血糖在重度组显著升高,与轻度组和中度组有显著性差异(P<0.05)。结论:轻度组、中度组、重度组肺功能逐渐下降,血糖水平逐渐升高,且对患者的预后有重要影响。

Objective： To investigate the initial blood glucose levels after admission in patients with acute exacerbation of chronic obstructive pulmonary disease,and to analyze its relationship with lung inflammation and prognosis. Methods： The patients with acute exacerbation of chronic obstructive pulmonary disease were divided into mild group 25 cases,moderate group 18 cases,severe group 15 cases after admission and immediately had random venous blood glucose,pulmonary function tests; and had fasting blood glucose in second day morning. Followed- up 6 months,and were recorded their pulmonary function. Results： Fasting blood glucose levels in the moderate group,and severe group was significantly increased,in the mild group had no obvious; and the patients who had high blood sugar levels,had lung function declined faster in 6 months;random blood glucose was significantly higher in the severe group after admission,there was significant difference（ P 0. 05）,and which was nocorrelation in the mild and moderate groups. Conclusion： In three groups the level of blood glucose is high gradually as well as the lung function is declined gradually,which has an important influence for the prognosis of the patients