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早期急性肾损伤标志物肾损伤分子1研究进展 被引量：6

Recent advances of early biomarker kidney injury molecule 1 for diagnosis of acute kidney injury
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摘要 肾损伤分子1(Kim-1)是一种Ⅰ型跨膜糖蛋白,在正常肾脏中不能检测出,但在肾脏缺血或者毒性损伤后在近端小管细胞的细胞膜顶端表达增强,能够促进损伤的上皮细胞修复。目前越来越多的研究表明Kim-1可能是代表急性肾损伤早期、无创的近端小管生物标志物。 Kidney injury molecule 1 （Kim-1） is a type Ⅰ transmembrane glycoprotein, which is absent in normal condition but elevated in the proximal tubule apical membrane cells after renal ischemia or toxic injury. Kim-1 is capable of facilitating repair of injured epithelia. Recently, more and more studies show that Kim-1 may represent an early, noninvasive biomarker for proximal tubular acute kidney injury.
作者 李引 杜晓刚
机构地区 重庆医科大学附属第一医院肾内科
出处 《中国医药导报》 CAS 2014年第35期166-168,F0003,共4页 China Medical Herald
关键词 急性肾损伤 肾损伤分子1 生物学标志 Acute kidney injury Kidney injury molecule-l Biomarker
分类号 R692.3 [医药卫生—泌尿科学]
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参考文献33

  • 1Li PK,Burdmann EA,Mehta RL. Acute kidney injury:Acute kidney injury-global health alert [J]. Nat Rev Nephrol,2013,9(3) :133-135.
  • 2Bellomo R,Roneo C,Kellum JA,et al. Aeute renal failure-definition, outcome measures, animal models, fluid therapy and information tech- nology needs:The second international consensus conference of the acute dialysis quality initiative (adqi)group [J]. Crit Care, 2004,8 (4) : R204-R212.
  • 3Chertow GM,Soroko SH,Paganirti EP,et al. Mortality after acute re- nal failure:Models for prognostic stratificatian and risk adjustment [J].Kidney Int,2006,70(6):1120-1126.
  • 4Ozer JS,Dieterle F,Troth S,et al. A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with im- proved potential to assess renal function [J]. Nat Biotechnol, 2010,28 (5) : 486-494.
  • 5Bonventre JV. Kidney injury molecule-1 (kim-1) :A specific and sensitive biomarker of kidney injury [J]. Scand J Clin Lab Invest Suppl, 2008,241 : 78-83.
  • 6Mishra J,Ma Q,Prada A,et al. Identification of neutrophil gelatinase- associated lipocalin as a novel early urinary biomarker for ischemic renal injury [J]. J Am Soc Nephrol,2003,14(10):2534-2543.
  • 7Munshi R,Johnson A,Siew ED,et al. Mcp-1 gene activation marks acute kidney injury [J]. J Am Soc biephro1,2011,22(1 ) : 165-175.
  • 8Adiyanti SS,Loho T. Acute kidney injury (aki)biomarker [J]. Acta Med Indones ,2012,44(3) :246-255.
  • 9Edelstein CL. Biomarkers of acute kidney injury [J]. Adv Chronic Kid- ney Dis,2008,15(3) :222-234.
  • 10Mussap M ,Noto A,Fanos V ,et al. Emerging hiomarkers and metabo- lomics for assessing toxic nephropathy and acute kidney injury (aki) in neonatology [J]. Biomed Res Int, 2014,2014 : 602526.

二级参考文献25

  • 1黄金波,胡丽华.Tim家族在免疫应答中的作用[J].现代免疫学,2006,26(5):434-437. 被引量：3
  • 2[1]McIntire JJ,Umetsu SE,Akbari O,et al.Identification of Tapr(an airway hyperreactivity regulatory locus)and the linked Tim gene family[J].Nat Immunol,2001,2:1109-1116.
  • 3[2]Kuchroo VK,Umetsu DT,DeKruyff RH,et al.The TIM gene family:emerging roles in immunity and disease[J].Nat Rev Immunol,2003,3:454-462.
  • 4[4]Santiago C,Ballesteros A,Tami C,et al.Structures of T cell immunoglobulin mucin receptors 1 and 2 reveal mechanisms for regulation of immune responses by the TIM receptor family[J].Immunity,2007,26:299-310.
  • 5[5]Cao E,Zang X,Ramagopal UA,et al.T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface[J].Immunity,2007,26:311-321.
  • 6[6]Monney L,Sabatos CA,Gaglia JL,et al.Th-2 specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease[J].Nature,2002,415:536-541.
  • 7[7]Silberstein E,Dveksler G,Kaplan GG.Neutralization of hepatitis A virus(HAV)by an immunoadhesin containing the cysteine-rich region of HAV cellular receptor-1[J].J Virol,2001,75:717-725.
  • 8[8]Tami C,Silberstein E,Manangeeswaran M,et al.Immunoglobulin A(IgA)is a natural ligand of hepatitis A virus cellular receptor 1(HAVCR1),and the association of IgA with HAVCR1 enhances virus-receptor interactions[J].J Virol,2007,81:3437-3446.
  • 9[9]Miyanishi M,Tada K,Koike M,et al.Identification of Tim4 as a phosphatidyl serine receptor[J].Nature,2007,450:435-439.
  • 10[10]Santiago C,Ballesteros A,Martinez-Mu(n)oz L,et al.Structures of T cell immunoglobulin mucin protein 4 show a metalion-dependent ligand binding site where phosphatidyl serine binds[J].Immunity,2007,27:941-951.

共引文献2

同被引文献68

  • 1赵新生,王鑫.正确评价多巴胺在重症患者中的使用[J].中国医刊,2004,39(8):18-21. 被引量：10
  • 2全国eGFR课题协作组.MDRD方程在我国慢性肾脏病患者中的改良和评估[J].中华肾脏病杂志,2006,22(10):589-595. 被引量：702
  • 3Che M, Li Y, Liang X, et al. Prevalence of acute kidney injury fol- lowing cardiac surgery and related risk factors in Chinese patients[J]. Nephron Clin Pract, 2011,117 (4) : c305-311.
  • 4Hobson CE, Yavas S, Segal MS, et al. Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery [ J ]. Circulation, 2009,119 ( 18 ) :2444-2453.
  • 5Palomba I-I, de Castro I, Neto AL, et al. Acute kidney injury prediction following elective cardiac surgery: AKICS Score [ J ]. Kidney Int, 2007,72(5 ) :624-631.
  • 6Dasta JF, Kane-Gill SL, Durtschi AJ, et al. Costs and outcomes of acute kidney injury (AKI) following cardiac surgery [ J ]. Nephrol Dial Transplant, 2008,23 ( 6 ) : 1970-1974.
  • 7Lassnigg A, Schmidlin D, Mouhieddine M, et al. Minimal chan- ges of serum creatinine predict prognosis in patients after cm'diotho- racic surgery : a prospective cohort study[ J ]. J Am Soc Nephrol, 2004,15 (6) : 1597-1605.
  • 8Kandler K, Jensen ME, Nilsson JC, et at. Acute kidney injury is in- dependently associated with higher mortality after cardiac surgery'[ J ]. J Cardiothorac Vasc Anesth, 2014,28 (6) :1448-1452.
  • 9Moguel-GonzOlez B, Wasung-de-Lay M, Tella-Vega P, et al. A- cute kidney injury in cardiac surgery[J]. Rev Invest Clin, 2013, 65 (6) :467-475.
  • 10Yoo.YC, Youn YN, Shim JK, et al. Effects of renin-angiotensin system inhibitors on the occurrence of acute kidney injury following off-pump coronary artery bypass grafting [ J ]. Circ J, 2010, 74(9) :1852-1858.

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中国医药导报
2014年 第35期

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