漳州地区献血人群不规则抗体筛查分析

Analysis of irregular antibody screening of blood donors in Zhangzhou

目的:探讨对献血者进行不规则抗体筛查的临床意义及其对保证输血安全的价值。方法:用盐水介质法对153 009例漳州地区献血人群的血浆标本进行不规则抗体筛查,用抗人球蛋白法做进一步鉴定。结果:153 009例标本不规则抗体筛选阳性92例(0.06%)。通过性别分组以及抗人球蛋白法进一步鉴定发现,58 440例女性献血者中检出不规则抗体为61例(0.104%),94 569例男性献血者中检出不规则抗体为31例(0.033%),女性组不规则抗体检出率高于男性组的不规则抗体检出率(P<0.01)。同时,检出的不规则抗体中IgM抗体65例(0.042%),IgG抗体27例(0.018%),IgM抗体检出率高于IgG抗体(P<0.01)。结论:对献血者进行不规则抗体检测能减少不规则抗体进入受血者体内的可能性,从而有效提高输血的安全性。

Objective：To explore the clinical significance of irregular antibody screening and its value to ensure the safety of blood transfusion. Method：A total of 153 009 serum or plasma samples from blood donors in zhang- zhou were screened by the tube agglutination, and identified by Coombs test for irregular antibodies. Result： Nine- ty-two were positive in 153 009 samples, and the positive rate was 0. 06% . The rate of irregular antibodies in fe- male （61/58 440） was higher than that in male（31/94 569）（P〈0.01）, and the IgM irregular antibodies （65/153 009） was higher than IGG（27/153 009） （P〈0.01）. Conclusion： Detection of irregular antibodies of donors blood could effeciently ensure the safety of blood transfusion.