C反应蛋白检测在输血不良反应中的应用

Application value of C-reactive protein to diagnosis of blood transfusion reactions

目的:探讨C反应蛋白(CRP)检测在输血不良反应中的应用价值,为输血不良反应的预防和干预提供参考依据。方法:选取2014-01-03辛集市第一医院发生发热反应的45例输血患者为发热组,发生过敏反应的39例输血患者为过敏组,无输血不良反应的71例输血患者为对照组。采用免疫荧光法测定输血前后的全血CRP水平。结果:1发热组和过敏组输血后CRP升高,与对照组比较,差异有统计学意义(P<0.05);2发热组和过敏组输血后CRP比较,发热组较高,差异有统计学意义(P<0.05);3发热组和过敏组输血反应前后的CRP比较,差异有统计学意义(P<0.05)。结论:CRP是一种非特异性的炎症指标,发生输血不良反应时CRP显著升高,CRP可能对输血不良反应的发生发展具有一定的预测价值。

Objective：To discuss the application value of C-reactive protein（CRP） for blood transfusion reac- tions, and provide theoretical reference basis for prevention and intervention blood transfusion reactions. Method： Fouty-five cases of blood transfusion patients with fever adverse reaction were choosed as fever group , 39 patients with allergic as allergic group, 71cases of blood transfusion patients without adverse reactions as control group be- tween January and March 2014 in First Hospital of Xinji City, Hebei. CRP levels in the whole blood were deter- mined by using immunofluorescence method before and after blood transfusion. Result： ①CRP levels after blood transfusion elevated in fever and allergic group, compared with control group respectively, the differences were statistically significant （P〈0.05）. ②CRP levels after blood transfusion CRP levels in fever group was higher than that in allergic group, which difference was statistically significant （P〈0.05）. （3）CRP levels before and after blood transfusion in two groups was compared, the difference was statistically significant （P〈0.05）. Conclusion：CRP is an inflammatory raarker which would rise significantly in blood transfusion reactions and determination of CRP would have certain application value to the diagnosis of blood transfusion reactions.