动脉粥样硬化危险因素的研究进展

Research progress of risk factors in atherosclerosis

已经确定的动脉粥样硬化的传统危险因素,如高脂血症、高血压、抽烟、糖尿病等并不能解释和预测所有心脑血管临床事件的发生。随着流行病学调查和实验室工作的深入,发现一些新的危险因素例如循环白细胞数量、血浆纤维蛋白原、尿酸、脂肪组织分布等在动脉粥样硬化的形成与发展过程中越来越发挥着举足轻重的作用。鉴于此,本研究针对相关最新研究进行简要阐述,力图为动脉粥样硬化的恶性演进提供相关实验与理论依据。

Traditional risk factor having been identified of atherosclerosis such as hyperlipidaemia,hypertension,smoking and diabetes couldn′t explain and predict the occurrence of all cardiovascular clinical events.With the development of epidemiological investigation and laboratory work,some novel risk factors such as circulating white blood cells,plasma fibrinogen,blood uric acid,adipose tissue distribution were found to play a very important role in the formation of atherosclerosis.So this study briefly expounds some latest progresses of related studies in order to provide evidences for the malignant evolution of atherosclerosis.