外周血核基因表达评价辐射生物剂量方法研究进展

Advances of nuclear gene expression signatures in peripheral blood for irradiation biodose estimation

基因芯片技术可以完整地了解辐射引起的细胞或组织差异基因表达变化,已广泛应用于放射生物学的研究.外周血有核细胞,特别是淋巴细胞对辐射非常敏感,全面了解辐射后外周血有核细胞基因表达变化,对于辐射生物剂量分子指标研究及建立剂量评价模型非常重要.该文总结了目前利用基因芯片技术筛选外周血辐射响应基因,并利用筛选基因表达信号建立评价模型等的研究现状.

As gene chip technology helps get a more comprehensive understanding of the differentially expressed genes in cells or tissues induced by ionizing radiation,it has been widely used in the research of radiobiology to screen biomarkers.The peripheral blood nucleated cells are extremely sensitive to ionizing radiation,especially lymphocytes.Therefore,it is important to better understand the gene expression changes of peripheral blood nucleated cells for studying molecular biomarkers of ionizing radiation biodosimetry and building the prediction model to estimate radiation exposures.The paper briefly describes the latest research progress in screening ionizing radiation response genes from peripheral blood by means of gene chip technology as well as building the prediction model using expression changes of screened genes.