静脉用氟康唑预防儿科重症细菌性肺炎发生真菌感染临床疗效观察

Intravenous Fluconazole Prophylaxis of Pediatric Severe Bacterial Pneumonia Clinical Curative Effect Observation of Fungal Infection

目的讨论并分析静脉用氟康唑在提前防治儿科重症细茵性肺炎长时间联合应用广谱抗生素后出现具有侵袭性真菌感染的临床的表现。方法从我院选取70例患有重症细菌性肺炎的患儿,任意的分成观察组和对照组各35例,观察组是采取预防性静脉用氟康唑的患儿,对照组是没有利用预防性静脉用氟康唑的患儿,回顾性对比研究两组患儿的临床方面的特征、侵袭性真茵感染的发生状态。结果两组患儿发生真菌感染的危险因素、临床特征不具有科学的统计学差异(P>0.05)。对照组发生侵袭性真菌感染5例(14.3%),预防组发生侵袭性真菌感染1例(2.9%),P<0.01,差异有科学性统计学意义。观察组和对照组肝功能情况无统计学差异。结论针对儿科重症细菌性肺炎长时间联合应用广谱抗生素的患儿,预防性静脉用氟康唑可很大程度降低发生侵袭性真菌感染的可能性,改变并完善预后,肝功能没有明显受到伤害。

Objective Discussion and analysis of intravenous fluconazole in the prevention and treatment of pneumonia after a long time in advance of the pediatric intensive bacteriological combined clinical performance of broad-spectrum antibiotics have invasive fungal infections. Methods Select suffering from severe bacterial pneumonia in children 70 cases from our hospital,arbitrary divided into observation group and control group of 35 cases,the observation group is to take preventive intravenous fluconazole in children, the control group was no use of prophylactic intravenous fluconazole in children, the clinical aspect of the retrospective comparative study of two groups of children with invasive infections occur Yin true state. Results Fungal infections occur in children with risk factors for the two groups, clinical features do not have a scientific statistical difference（P〉0.05）. Control of invasive fungal infections occurred in 5 patients（14.3%）, the occurrence of invasive fungal infections prevention group 1 cases（2.9%）, P〈0.01, statistically significant differences were scientific. Observation group and the control group no significant difference in liver function. Conclusion For a long time pediatric intensive combination of bacterial pneumonia in children with broad-spectrum antibiotics, prophylactic intravenous possibility can largely reduce the incidence of invasive fungal infections fluconazole, change and improve the prognosis of liver function is not obviously hurt.