49例结核性脑膜炎临床及脑脊液特征分析

Analysis of the clinical and cerebrospinal fluid characteristics of 49 cases with tuberculous meningitis

目的:分析结核性脑膜炎临床及脑脊液特征。方法:回顾性分析49例结核性脑膜炎患者的临床资料,按照临床特征将所有患者分为Ⅰ组(脑神经麻痹,29例)和Ⅱ组(无脑神经麻痹,20例),比较分析两组患者的脑脊液常规及生化特征。结果:Ⅰ组CT扫描异常率为96.6%,略高于Ⅱ组的90.0%,但组间差异无统计学意义(P>0.05);Ⅰ组患者脑脊液蛋白含量明显高于Ⅱ组,两组间差异有统计学意义(P<0.05);Ⅰ组患者脑脊液中Ig G、Ig M、Alb含量与Ⅱ组比较,差异均有统计学意义(P<0.05)。结论:结核性脑膜炎常伴有脑神经损害,临床医师应熟练掌握该疾病的临床及脑脊液特征,及早诊治,改善患者预后。

Objective To analyze thv clinical and cerebrospinal fluid characteristics of 49 cases with tuberculous meningitis. Method The clirdcal data of 49 cases with tuberculous meningitis was retrospectively analyzed, the patients were divided into group Ⅰ （ cranial nerve palsy,29 cases） and group Ⅱ （no cranial nerve palsy ,20 eases） according to clinical characteristics,in the two groups, the conventional and biochemical characterieties of cerebrospinal fluid were compared and analyzed. Results The abnormal rate of CT scan in group Ⅰ was 96. 6% ,It was slightly higher than 90. 0% of group Ⅱ ,hut there was no significant difference between groups （P〉0. 05） ; the protein content of ccrebrosplnal fluid in group Ⅰ was significantly higher than group Ⅱ ,the difference was statistically significant between the two groups （P 〈0, 05） ;the IgG,IgM,Alb content of cerebrospinal fluid in group Ⅰ compared to group Ⅱ ,the differences were statistically significant （P 〈 0. 05 ）. Conclusion Tuberculous meningitis is often cocurrent with cranial nerve palsy, clinicians should be familiar with the clinical and eerehrospinal fluid characteristics of the disease, early diagnosis and treatment, improve the prognosis of patients.