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微囊泡与2型糖尿病大血管病变关系的研究进展

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摘要 微囊泡（microvesicles,MVs）是细胞在某些生理或病理状况下受到激活或凋亡,从细胞膜表面直接出芽脱落形成的小囊泡样物质.2型糖尿病（T2DM）大血管病变的多种危险因素均可刺激MVs形成,在T2DM和心血管疾病中MVs水平明显升高.MVs可通过介导内皮细胞损伤、血栓形成、斑块破裂及侧支循环形成障碍等病理过程参与糖尿病大血管病变的发生发展.目前研究认为,MVs有望成为T2DM大血管病变诊断、评估预后和疗效判定的潜在生物标志物.现就MVs与T2DM大血管病变的研究进展综述如下.
作者 王颖 陈莉明
机构地区 天津医科大学代谢病医院糖尿病肾病科卫生部激素与发育重点实验室
出处 《中华糖尿病杂志》 CAS CSCD 2014年第11期831-834,共4页 CHINESE JOURNAL OF DIABETES MELLITUS
关键词 糖尿病大血管病变 2型糖尿病 囊泡 内皮细胞损伤 T2DM 心血管疾病 生物标志物 病理状况
分类号 R587.2 [医药卫生—内分泌]
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参考文献31

  • 1Diem P, Fricke A, Sander L, et al. Mieroparticles: major transport vehicles for distinct microRNAs in circulation[J]. Cardiovasc Res, 2012,93:633-644.
  • 2Csongr6di l~, Nagy B Jr, Fulop T, et al. Increased levels of platelet activation markers are positively associated with carotid wall thickness and other atherosclerotic risk factors in obese patients[J]. Thromb Haemost,2011,106:683-692.
  • 3Li CJ, Liu Y, Chert Y, et al. Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke[J]. Am J Pathol,2013,182:1552-1562.
  • 4Sinning JM, Losch J, Walenta K, et al. Circulating CD31 +/ Aunexin V + microparticles correlate with cardiovascular outcomes[J]. Eur Heart .1,2011,32:2034-2041.
  • 5Liu ML, Reilly MP, Casasanto P, et al. Cholesterol enrichment of human monocyte/macrophages induces surface exposure of phosphatidylserine and the release of biologically-active tissue factor-positive microvesicles[J]. Arterioscler Thromb Vasc Biol, 2007,27:430-435.
  • 6Shimazu T, Inami N, Satoh D, et al. Effect of acarbose on platelet-derived micropartieles, soluble seleetins, and adiponectin in diabetic patients[J]. J Thromb Thrombolysis, 2009,28:429-435.
  • 7Alkhatatbeh M J, Enjeti AK, Acharya S, et al. Tile origin of circulating CD36 in type 2 diabetes[,1]. Nutr Diabetes,2013,3: e59.
  • 8Tramontano AF, Lyubarova R, Tsiakos J, et al. Circulating endothelial microparticles in diabetes mellitus[J]. Mediators Inflamm,2010,2010:250476.
  • 9Kurtzman N, Zhang L, French B, et al. Personalized eytomic assessment of vascular health: Evaluation of the vascular health profile in diabetes mellitus[J]. Cytometry B Clin Cytom, 2013,84: 255-266.
  • 10Jung KH, Chu K, Lee ST, et al. Risk of macrovascular complications in type 2 diabetes mellitus: endothelial microparticle profiles[J]. Cerebrovasc Dis,2011,31:485-493.

二级参考文献21

  • 1Ogden CL, Carroll MD, Kit BK, the United States, 2009-2020 [ J ] 1-8. et al. Prevalence of obesity in NCHS Data Brief, 2012,82 :.
  • 2Berrington de Gonzalez A, Hartge P, Cerhan JR, et al. Body- mass index and mortality among 1.46 million white adults [ J ]. N Engl J Med,2010,363 :2211-2219.
  • 3Mechanick JI, Garber A J, Handelsman Y, et al. American Association of Clinical Endocrinologists (AACE) position paper on obesity and obesity medicine [ J ]. Endocr Pract, 2012, 18: 642-648.
  • 4Ryan DH, Johnson WD, Myers VH, et al. Nonsurgieal weight loss for extreme obesity in primary care settings: results of the Louisiana Obese Subjects Study [ J]. Arch Intern Med, 2010, 170 : 146-154.
  • 5Livingston EH. The incidence of bariatrie surgery has plateaued in the U. S[JI. Am J Surg, 2010,200:378-385.
  • 6Meehanick JI, Kushner RF, Sugerman HJ, et al. American Association of Clinical Endocrinologists, The Obesity Society, and the American Society for Metabolic & Bariatric Surgery medical guidelines for clinical practice for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient [J]. Endocr Pract, 2008,14 Suppl 1 :S1-83.
  • 7American Society for Metabolic Bariatric Surgery. Updated position statement on sleeve gastrectomy as a bariatrie procedure[ EB/OL]. [2013-12-23 ]. http://www, thinnertimesforum, com/topic/65864- october-2011 -sleeve-gastrectomy-position-statement -fromasmbs/.
  • 8Hutter MM, Schirmer BD, Jones DB, et al. First report from the American College of Surgeons Bariatric Surgery Center Network: laparoseopic sleeve gastrectomy has morbidity and effectiveness positioned between the band and the bypass[ J]. Ann Surg,2011, 254:410-420.
  • 9O'Brien PE, Dixon JB, Laurie C, et al. Treatment of mild to moderate obesity with laparoscopic adjustable gastric banding or an intensive medical program : a randomized, trial [ J 1. Ann Intern Med, 2006,144:625-633.
  • 10Sultan S, Parikh M, Youn H, et al. Early U.S. outcomes after laparoscopic adjustable gastric banding in patients with a body mass index less than 35 kg/m2 [ J：. Surg Endosc,2009,23 : 1569- 1573.

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中华糖尿病杂志
2014年 第11期

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