富血小板血浆制备技术及其组分的研究进展

RESEARCH PROGRESS OF PREPARATION AND COMPONENTS OF PLATELET RICH PLASMA

目的总结富血小板血浆(platelet rich plasma,PRP)的制备技术及其组分的研究进展。方法广泛查阅近年国内外有关PRP的作用机制、制备方法以及组成等相关文献,并进行总结分析。结果 PRP促进生物学修复作用的发挥依赖于一系列序贯发生的级联细胞分子事件。PRP中含有高浓度血小板,其激活后释放大量活性因子,还含有少量的白细胞和红细胞。PRP的制备基于血小板的浓缩技术,不同的制备技术获得的血小板浓度、复苏率和组分也不相同。结论 PRP的制备技术目前尚无统一标准,不同的制备方法获得的不同成分和不同浓度的PRP,为临床患者选择最适合的个体化PRP产品奠定基础。

Objective To review the research progress of the preparation and components of the platelet rich plasma（PRP）.Methods The recent literature concerning the biological mechanism,preparation,and components of PRP was analyzed and summarized.Results The biological function of PRP depends on a series of intricate cascade of cellular and molecular events.PRP contains different concentrations of platelets,which would release a large number of the activated molecules,and also contains a small amount of white blood cells and red blood cells.The preparation of PRP is based on platelet concentration.Different preparation techniques would lead to different platelet concentrations,recovery ratios,and components.Conclusion There is no uniform standard for the preparation of PRP.Different preparation methods and technical parameters of PRP will get different components and different concentrations of PRP,which also provide a reference for clinicians to select the most appropriate PRP for individual patient.