微流控技术筛选酶抑制剂的研究进展

Advances in enzyme inhibitor screening based on microfluidic technology

随着近年新合成或提取的化合物大量涌现,药物筛选朝着快速、高效、高通量方向发展。微流控分析技术具有的分析微型化、高通量化、可集成化和良好的生物相容性等特点,为药物的筛选提供了新的方法和技术平台。本文简要介绍了酶抑制剂筛选,重点评述基于微流控技术筛选酶抑制剂的研究进展。

With the emerging of a mass of new compounds,approaches of drug screening developed constantly,making drug screen-ing develop rapidly,efficiently and high throughput. Microfluidic analysis technology,with such significant features as miniaturiza-tion,high-throughput,integration and good biocompatibility, provided a new method and technology platform for the screening of drugs. This review introduced the conventional methods of enzyme inhibitor screening,especially focused on recent developments of enzyme inhibitor screening based on the microfluidic technology.