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细胞色素P450 2E1在酒精性脂肪肝发病中作用的研究进展 被引量:3

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摘要 酒精性肝病(alcoholic liver disease,ALD)是过度饮酒引起的一类肝脏疾病,包括脂肪肝、肝炎、肝纤维化和肝硬化等.流行病学调查显示,ALD已成为严重影响中国居民健康的公共卫生问题[1].酒精性脂肪肝(alcoholic fatty liver,AFL)是ALD的早期阶段,因具有可逆性,曾一度被视为一种良性病变.然而近年的研究表明,脂肪变性的肝细胞对肿瘤坏死因子-α(tumor necrosis factor α,TNF-α)等敏感性增强,且部分AFL患者在戒酒后仍然会进展为肝炎、肝纤维化、甚至肝硬化[2-3].AFL是一种临床上的常见疾病,在饮酒量>60 g/d的人群中发病率高达90%以上[4].
出处 《中华劳动卫生职业病杂志》 CAS CSCD 北大核心 2014年第11期877-880,共4页 Chinese Journal of Industrial Hygiene and Occupational Diseases
基金 国家自然科学基金(81102153) 山东省博士后创新专项基金(201002020)
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