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CCDC8基因表达与乳腺癌分子分型的相关性研究 被引量：5

The Correlation of between CCDC8 Gene and Molecular Subtype of Breast Cancer
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摘要 目的探讨CCDC8在乳腺癌组织中的表达及其与乳腺癌分子分型的关系.方法采用免疫组化分析CCDC8在100例乳腺癌组织的表达情况及其与乳腺癌分子分型相关性.结果 CCDC8在乳腺癌组织的阳性表达率为38%在数值上可见;CCDC8基因阳性表达率在ER、PR阳性组高于ER、PR阴性组,在Ki67阴性组高于Ki67阳性组(P>0.05);但CCDC8基因的表达在ER、PR、Her-2、Ki67、分子分型分组中未发现差异有统计学意义.结论 CCDC8基因阳性表达率在ER阳性组、PR阳性组、Ki67阴性组较高,暂未发现CCDC8基因与乳腺癌分子分型的相关性. Objective To determine the relation between CCDC8 gene and molecular subtype of breast cancer.Methods One hundred breast cancer tissue samples were collected in this study,and HIC was performed to investigate the expression of CCDC8 in breast tissue.Tumor characteristics （estrogen and progesterone receptor,Her-2,Ki67） were recorded.Results The positive expression of CCDC8 in breast cancer was 38％.The positive expression of CCDC8 in ER,PR positive group was higher than negative group,in Ki67 negative group was higher than positive group.But no correlation was found between CCDC8 and estrogen and progesterone receptor,Her-2,Ki67 and molecular subtype.Conclusion The positive expression of CCDC8 in ER,PR positive group and Ki67 negative group is higher,but there is no correlation between CCDC8 and molecular subtype.
作者 李云芬 唐一吟 王建逵 杨承钢 陈芸 聂建云
机构地区 昆明医科大学 昆明医科大学第三附属医院
出处 《昆明医科大学学报》 CAS 2014年第12期24-28,53,共6页 Journal of Kunming Medical University
基金 国家自然科学基金资助项目(81360392) 云南省应用基础研究基金资助项目(2012FB063)
关键词 CCDC8 乳腺癌 分子分型 免疫组化 CCDC8 Breast cancer Molecular subtype HIC
分类号 R786 [医药卫生—口腔医学] R739 [医药卫生—肿瘤]
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参考文献13

  • 1SIEGEL R,NAISHADHAM D,EMAL A.Cancer statistics,2012[J].CA:a cancer journal for clinicians,2012,62 (1):10-29.
  • 2HUNTER D J,KRAFT P,JACOBS K B,et al.A genomewide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer[J].Nature genetics,2007,39(7):870-874.
  • 3BANGE J,ZWICK E,ULLRICH A.Molecular targets for breast cancer therapy and prevention[J].Nat Med,2001,7 (5):548-52.
  • 4李云芬,张婷,陶春英,刘馨,聂建云.CCDC8基因在乳腺癌中的表达[J].肿瘤研究与临床,2014,26(4):226-229. 被引量：4
  • 5GOLDHIRSCH A,WOOD W C,COATES A S,et al.Strategies for subtypes-dealing with the diversity of breast cancer:highlights of the St.Gallen international expert consensus on the primary therapy of early breast cancer 2011.annals of oncology:official journal of the European Society for Medical Oncology / ESMO,201 1,22(8):1 736-1 747.
  • 6HANSON D,MURRAY P G,O'SULLIVAN J,et al.Exome sequencing identifies CCDC8 mutations in 3-M syndrome,suggesting that CCDC8 contributes in a pathway with CUL7 and OBSL1 to control human growth[J].American journal of human genetics,2011,89 (1):148-153.
  • 7HANSON D,MURRAY P G,BLACK G C,et al.The genetics of 3-M syndrome:unravelling a potential new regulatory growth pathway[J].Hormone research in paediatrics,2011,76(6):369-378.
  • 8DAI C,TANG Y,JUNG S Y,et al.Differential effects on p53-mediated cell cycle arrest vs.apoptosis by p90[J].Proceedings of the National Academy of Sciences of the United States of America,2011,108 (47):18 937-18 942.
  • 9DRUCKER K L,KITANGE G J,KOLLMEYER T M,et al.Characterization and gene expression profiling in glioma cell lines with deletion of chromosome 19 before and after microcell-mediated restoration of normal human chromosome 19.Genes,chromosomes & cancer,2009,48 (10):854-864.
  • 10LAW J H,LI Y,TO K,et al.Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability[J].PLoS One,2010,5(9):661-664.

二级参考文献13

  • 1Merlo DF,Ceppi M,Filiberti R,et al.Breast cancer incidence trends in European women aged 20-39 years at diagnosis[J].Breast Cancer Res Treat,2012,134:363-370.
  • 2Hunter DJ,Kraft P,Jacobs KB,et al.A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer[J].Nat Genet,2007,39:870-874.
  • 3Bange J,Zwick E,Ullrich A.Molecular targets for breast cancer therapy and prevention[J].Nat Med,2001,7:548-52.
  • 4Law JH,Li Y,To K,et al.Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability[J].PLoS One,201 0,5:e1 2661.
  • 5Cheang MC,Chia SK,Voduc D,et al.Ki-67 index,HER2 status,and prognosis of patients with luminal B breast cancer[J].J Natl Cancer Inst,2009,101:736-750.
  • 6Hanson D,Murray PG,O'Sullivan J,et al.Exome sequencing identifies CCDC8 mutations in 3-M syndrome,suggesting that CCDC8 contributes in a pathway with CUL7 and OBSL1 to control human growth[J].Am J Hum Genet,2011,89:148-153.
  • 7Hanson D,Murray PG,Black GC,et al.The genetics of 3-M syndrome:unraveling a potential new regulatory growth pathway[J].Horm Res Paediatr,2011,76:369-378.
  • 8Dai C,Tang Y,Jung SY,et al.Differential effects on p53-mediated cell cycle arrest vs.apoptosis by p90[J].Proc Natl Acad Sci U S A,2011,108:18937-18942.
  • 9Drucker KL,Kitange GJ,Kollmeyer TM,et al.Characterization and gene expression profiling in glioma cell lines with deletion of chromosome 19 before and after microcell-mediated restoration of normal human chromosome 19[J].Genes Chromosomes Cancer,2009,48:854-864.
  • 10Chen SL,Wu YS,Shieh HY,et al.p53 is a regulator of the metastasis suppressor gene nm23-Hl[J].Mol Carcinog,2003,36:204-214.

共引文献3

同被引文献58

  • 1GIBBINGS D,MOSTOWY S,JAY F,et al. Corrigendum: Selective autophagy degrades DICER and AGO2 and regulates miRNA activity [ J ]. Nat Cell Biol, 2015,17 (8): 1 088--1 091.
  • 2PRODROMAKI E,KORPETINOU A,GIANNOPOULOU E,et al. Expression of the microRNA regulators Drosha, Dicer and Ago2 in non-small cell lung carcinomas [J]. Cell Oncol (Dordr) ,2015,38(4):307--317.
  • 3MERRITF W M, LIN Y G, HAN L Y, et al. Dicer, Drosha, and outcomes in patients with ovarian cancer[J]. N Engl J Med,2008,359(25):2641--2650.
  • 4AHMAD A, GINNEBAUGH K R,YIN S,et al. Functional role of miR-lOb in tamoxifen resistance of ER-positive breast cancer cells through down-regulation of HDAC4 [J]. BMC Cancer,2015, 24(15):540--545.
  • 5HUANG J,SUN C,WANG S,et al. micoRNA miR-lOb inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells [J]. Mol Biosyst, 2015, 11 (7):2 051 --2 059.
  • 6MEDIMEGH I, OMRANE I, PRIVAT M, et al. MicroRNAs exp'ession in triple negative vs non tiple negative breast cancer it Tunisia'. interaction with clinical outcome [J ]. PLoS One, 2014,9( 11 ):el 11 877.
  • 7EISSA S, MATBOLI M, SHEHATA H H, et al.MicroRNA 10b and minichromosome maintenance complex component 5 gene as prognostic biomarkers in breast cancer[J]. Tu- rnout Biol,2Ol5,36(6):4 487--4 494.
  • 8AVERY-KIEJDA K A,BRAYE S G,FORBES J F,et al. The expression of Dicer and rosha in matched normal tis- sues, tumours and lymph node metastases in triple negative breast cancer[ J ]. BMC Cancer, 2014, 11 ( 14):253--257.
  • 9POURSADEGH ZONOUZI A A,NEJATIZADEH A, RAHMATI-YAMCHI M F,et al. Dysregulated expression of Dicer in invasive ductal breast carcinoma[J]. Med On- col, 2015,32(7 ):203--213.
  • 10GU L, SMITH S, LI C, et al. A PCNA-derived cell perme- able peptide selectively inhibits neuroblastoma cell growth [J]. PLoS One,2014,9(4):e94 773.

引证文献5

二级引证文献9

昆明医科大学学报
2014年 第12期

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