OCT在小鼠眼底检查中的研究进展

Developments in mice fundus examination using optical coherence tomography

OCT是应用测量光回波时间延迟的原理而获得被测组织的分层,该成像技术提供的视网膜断层截面图与组织形态学有很好的相关性 . 该技术目前也广泛应用于动物实验研究,特别是在小鼠的视网膜疾病研究中可以获取高分辨率的活体组织图像.现对小鼠视网膜OCT图像的成像装置、成像质量、图像分析、血流成像、疾病模型研究等方面的进展进行综述.

Spectral-domain optical coherence tomography （SD-OCT） is a method that provides depth profiles of the fundus that correlate well with histological data based on the measurement of light echo time delay,It has been used in animal experiments in recent years,especially in the study of the retina in mice.It produces a high-quality live image of mice retina in vivo.This review presents the most recent progress on the value of using OCT devices for research on image quality,biometry,retinal blood flow imaging and disease models.