低分子肝素钙联合硫酸镁与酚妥拉明治疗肺源性心脏病急性加重期的效果

Clinical effect of low molecular heparin calcium combined with magnesium sulfate and phentolamine on acute exacerbation of pulmonary heart disease

目的 观察低分子肝素钙联合硫酸镁、酚妥拉明治疗肺源性心脏病急性加重期的临床效果.方法 选择商丘市第四人民医院收治的符合入选标准的肺源性心脏病急性加重期患者108例,随机分为治疗组54例和对照组54例,两组患者均常规给予抗感染、吸氧、止咳祛痰、解痉平喘、强心利尿、纠正电解质紊乱等治疗,治疗组在常规治疗的基础上加用低分子肝素钙、硫酸镁和酚妥拉明注射液,10 d为1个疗程.观察两组患者的疗效、治疗前后血流变及血气分析指标的差异.结果 治疗组总有效率为88.9％,对照组总有效率为70.4％,治疗组的疗效明显优于对照组（P＜0.05）;治疗组血流变及血气分析指标改善程度明显优于对照组（P均＜0.05）.结论 低分子肝素钙联合硫酸镁、酚妥拉明治疗肺源性心脏病急性加重期有良好的协同作用,能改善心肺功能,改善肺源性心脏病患者预后,可在临床推广应用.

Objective To observe the clinical effect of low molecular heparin calcium combined with magnesium sulfate and phentolamine on acute exacerbation of pulmonary heart disease.Methods One hundred and eight pulmonary heart disease patients in acute aggravating period were randomly divided into two groups：the treatment group with 54 cases and the control with 54 cases.The two groups were routinely given anti-infection,oxygen,cough expectorant,spasmolysis and asthma,strong heart,diuresis,correct electrolyte disturbances and so on.In addition,the patients in the treatment group were given low molecular heparin calcium,magnesium sulfate and phentolamine injection,taken 10 d as a course of treatment.The therapeutic effect,the difference of hemorrheology and blood gas analysis indexes before and after treatment between the two groups were observed.Results The total effectiveness of the treatment group was 88.9%,and the total effectiveness of the control group was 70.4%,the curative effect of the treatment group was better than that of the control group （P 〈 0.05） ; the improvement of blood gas analysis indexes in the treatment group were much better than those in the control group （all P 〈 0.05）.Conclusions There is a good synergistic effect when low molecular heparin calcium combined with magnesium sulfate and phentolamine in the treatment of patients with acute exacerbation of pulmonary heart disease.It can improve the cardiopulmonary function and the prognosis of patients with pulmonary heart disease,and can be popularized in clinical application.