劳拉西泮联合氟西汀治疗卒中后情感障碍的相关研究

Correlation study of lorazepam combined with fluoxetine in treatment of affective disorder after stroke

目的 探讨劳拉西泮联合氟西汀治疗卒中后情感障碍的可行性及临床效果.方法 回顾性分析2011年8月至2012年8月安阳市第二人民医院收治的84例脑卒中后精神抑郁患者的临床资料,将84例患者随机分为对照组40例和观察组44例,对照组单用抗抑郁药治疗,观察组则联合劳拉西泮和氟西汀用药治疗,采用汉密尔顿抑郁量表（HAMD）和睡眠障碍量表（SDRS）评定治疗效果.结果 两组治疗1周和6周后HAMD、SDRS评分均呈逐渐下降趋势,治疗前后对比差异有统计学意义（P＜0.05）.观察组治疗6周后总有效率为88.6％,远高于对照组的77.6％ （P ＜0.05）.结论 劳拉西泮联合氟西汀用药可显著改善脑卒中后患者情感障碍,疗效确切,但需注意用量,避免不良反应.

Objective To investigate the feasibility and clinical effects of lorazepam combined with fluoxetine in the treatment of affective disorder after stroke.Methods The clinical data of 84 patients with affective disorder after stroke from August 2011 to August 2012 in the second people＆#39;s hospital of Anyang were retrospectively analyzed.Eighty-four patients were randomly divided into control group （40 cases） and observation group （44 cases） ; patients in control group were given antidepressant drug treatment,and patients in observation group were treated with lorazepam and fluoxetine.The therapeutic effect were evaluated by using the Hamilton depression scale （HAMD） and sleep disorder scale （SDRS）.Results The HAMD,SDRS score of the two groups showed a gradual downward trend after 1,6 weeks treatment,and there was a significant difference before and after treatment （P 〈 0.05）.After 6 weeks of treatment,the total effective rate was 88.6% in observation group and 77.6% in control group（P 〈0.05）.Conclusions Lorazepam combined with fluoxetine treatment can significantly improve the affective disorder in patients post-stroke,but the reasonable amount should be addressed to avoid the adverse reactions.