调胃舒颗粒剂对萎缩性胃炎大鼠的治疗机制研究

Research of Treatment Mechanism on Atrophic Gastritis in Rats with Tiaoweishu Granules

目的:研究调胃舒颗粒剂对慢性萎缩性胃炎大鼠胃黏膜病理改变、增殖细胞核抗原和核转录因子的影响,探讨其作用机制。方法:40只SD大鼠随机分为正常对照组、模型组、调胃舒颗粒剂治疗组、三九胃泰组。每组10只。在造模成功后分别给予调胃舒颗粒剂水溶液,三九胃泰颗粒水溶液灌胃治疗。治疗结束后观察大鼠胃黏膜病理改变、核转录因子平均光密度和增殖细胞核抗原增殖指数。结果:与三九胃泰治疗比较,TG治疗后的核转录因子平均光密度和增殖细胞核抗原增殖指数均显著优于前者(P<0.05)。其病理图片与三九胃泰组比较,胞核阳性弱,范围小,阳性区域局限。结论:表明TG对大鼠CAG的治疗中,在病理改变、核转录因子平均光密度和增殖细胞核抗原增殖指数改善方面均优于三九胃泰治疗。

Objective ： To research the effect of Tiaoweishu Granules on gastric mucosa pathological changes, PCNA andnuclear factor - kB of atrophic gastritis in rats and its action mechanism was explored. Methods ：40 SD rats were randomlydivided into normal control group, model group, Tiaoweishu Granules treatment group and Sanjiu Weitai group. There were10 rats in each group. After successful modeling, rats were given Tiaoweishu Granules aqueous solution, water solution ofSanjiu Weitai Granules intragastrically. At the end of treatment, the gastric mucosa pathological changes in rats were ob-served. The average optical density of nuclear factor - kB and PCNA proliferation index were surveyed too. Results ： Theaverage optical density of nuclear factor - kB and PCNA proliferation index of Tiaoweishu Granules treatment group weresignificantly better than that of Sanjiu Weitai group（P 〈 0.05 ）. There were weak and relatively small polarity nucleus inthe pathological images compared with Sanjiu Weitai group. Conclusion：Effect of Tiaoweishu Granules was significantlybetter than Sanjiu Weitai on atrophic gastritis in rats to improve the gastric mucosa pathological changes and the averageoptical density of nuclear factor - kB and PCNA proliferation index.